广西莪术、团花、角茴香的化学成分及抗炎镇痛活性研究

	广西莪术、团花、角茴香的化学成分及抗炎镇痛活性研究; Chemical constituents of Curcuma kwangsiensis, Neolamarckia cadamba, Hypecoum erectum and their anti-inflammatory and analgesic bioactivities
	袁海恋
导师	罗晓东
摘要	This dissertation investigated anti-inflammatory and analgesic activities of crude extract and various fractions from Curcuma kwangsiensis, Neolamarckia cadamba, and Hypecoum erectum in vivo and in vitro, and this studies validate their traditional application. the forementioned three medicinal plants were phytochemically studied, and a total of 84 compounds were isolated, which contains 15 new ones (3 novel skeleton ones), by various chromatography techniques. The structures of all the isolates were established based on extensive spectroscopic data, quantum computational chemistry methods and X-ray diffraction analysis. Moreover, some major compounds and trace compounds isolated from the three plants were evaluated for anti-inflammatory and analgesic activities in vivo and in vitro. The aforementioned studies further certify traditional use and effective fraction of the three medicinal plants, which not only would account for scientific knowledge for their traditional use, but also provide credible theoretical foundation for the further development of anti-inflammatory and antinociceptive agents. The dissertation consists of three chapters, which detailedly demonstrates the chemical constituents and anti-inflammatory and antinociceptive effects of C. kwangsiensis, N. cadamba, and H. erectum by more comprehensively phytochemical and pharmacological studies, respectively. The structural type of the isolates involved in terpenoids, alkaloids (monoterpenoid indole and isoduinoline), phenylpropanoids, Phenolic glycosides and so on. Moreover, the pharmacological results exhibited partial isolates with anti-inflammatory and antinociceptive effects. Compounds isolated from the aforementioned three medicinal plants are listed below, and their chemical structures are exhibited in the following figures. 1 Anti-inflammatory and Antinociceptive effects of C. kwangsiensis and Its Chemical Constituents “Curcumae Radix”, the dried rhizomes of C. kwangsiensis (Zingiberaceae) documented in Chinese pharmacopoeia, which have been recorded in Chinese pharmacopoeia (2020 edition) and used to treat jaundice and red urine, the heart-fire and depression, arthralgia, and dysmenorrhea. According to its traditional use, various fractions from C. kwangsiensis were investigated with anti-inflammatory and antinociceptive actions in vivo, and the results indicates the EA fraction exhibited better activity. Subsequent phytochemical investigation on EA fraction of C. kwangsiensis led to the isolates of 36 compounds, including 34 terpenoids (three new ones) and two curcumin consitituents. Four major sesquiterpenoids (4, 6, 14, and 15) were achieved for their anti-inflammatory and antinociceptive assays models in vivo. some compounds were evaluated for their anti-inflammatory effects via detecting inflammatory mediator releases (COX-2, IL-1β, and TNF-α) in RAW 264.7 macrophage cells induced by LPS. the majority of sesqui- and diterpenoids isolated (3, 4, 6, 17, 18, and 21) could i
	2020-11
文献类型	学位论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74233
专题	昆明植物所硕博研究生毕业学位论文
推荐引用方式 GB/T 7714	袁海恋. 广西莪术、团花、角茴香的化学成分及抗炎镇痛活性研究, Chemical constituents of Curcuma kwangsiensis, Neolamarckia cadamba, Hypecoum erectum and their anti-inflammatory and analgesic bioactivities[D],2020.

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