基于天然产物Nocardioazine A和B的合成研究

	基于天然产物Nocardioazine A和B的合成研究; Studies Based on the Synthesis of Nocardioazines A and B
	王明忠
导师	罗晓东
摘要	Nocardioazine A and B are indole heterocyclic derivatives, isolated from an Australian marine sediment-derived sample, Nocardiopsis sp. (CMB-M0232). The bridged diketopiperazine-indole skeleton in nocardioazine A and B is a new class of prenylated diketopiperazine. The bioloical activities of nocardioazine A and B against colon cancer cells verify that is a new class of noncytotoxic P-gp inhibitor. The thesis concluded the studies toward the total synthesis of nocardioazine A and B. The achievements in this thesis can be summarized as follows: 1. The first total synthesis of the indole alkaloid nocardioazine B was accomplished in 10 steps with an overall yield of 11.8%. 2. Establishing the absolute stereochemistry and fulling the 13C-NMR data of nocardioazine B. 3. Six synthesis routes to nocardioazine A were studied. And the epoxidation intermediate (29) was obtained. 4. It will be further to understand the relationships between the structure and the effect of nocardioazines through comparing the biological activities of these analogs (29, 73 and so on) with nocardioazine A and B.
	2020-06
文献类型	学位论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74187
专题	昆明植物所硕博研究生毕业学位论文
推荐引用方式 GB/T 7714	王明忠. 基于天然产物Nocardioazine A和B的合成研究, Studies Based on the Synthesis of Nocardioazines A and B[D],2020.

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