Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis.

doi:10.1007/s13659-021-00313-0

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	Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis.
	Wei,Shu-Ya; Hu,Dong-Bao; Xia,Meng-Yuan; Luo,Ji-Feng; Yan,Hui; Yang,Jing-Hua; Wang,Yun-Song; Wang,Yue-Hu
	2021
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	11 期号:5 页码:545-555
摘要	One novel spirolactone, aquilarisinolide (1), three new sesquiterpenoids, (2R,4S,5R,7R)-2-hydroxyeremophila-9,11-dien-8-one (2), (1R,4S,5S,7R,11R)-13-hydroxyepidaphnauran-9-en-8-one (3), and (4R,5S,7R,8S,10S,13R)-8,13-dihydroxyrotunda-1,11-dien-3-one (4), together with 13 known compounds (5-17) were isolated from the resinous heartwood of Aquilaria sinensis (Thymelaeaceae). The structures of the new compounds were elucidated based on the analysis of NMR and MS data and theoretical calculations their ECD spectra. The isolated compounds were evaluated for their protective activities against PC12 cell injury induced by corticosterone (CORT) and 1-methyl-4-phenylpyridine ion (MPP+), as well as inhibitory activities against BACE1. Compound 4, 5,6-dihydroxy-2-(2-phenylethyl)chromone (5), daphnauranol B (7), 6-methoxy-2-[2-(3-methyoxyphenyl)ethyl]chromone (10), isoagarotetrol (14), and 1-hydroxy-1,5-diphenylpentan-3-one (16) showed significant protective effects on CORT-induced injury in PC12 cells at a concentration of 20muM (P<0.001). Isoagarotetrol (14) showed a significant protective effect on MPP+-induced injury in PC12 cells at a concentration of 20muM (P<0.001), while compound 4 showed a moderate activity (P<0.01). The BACE1-inhibitory activities of all tested compounds were very weak with less than 30% inhibition at a concentration of 20muM.
DOI	10.1007/s13659-021-00313-0
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73797
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wei,Shu-Ya,Hu,Dong-Bao,Xia,Meng-Yuan,et al. Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis.[J]. Natural products and bioprospecting,2021,11(5):545-555.
APA	Wei,Shu-Ya.,Hu,Dong-Bao.,Xia,Meng-Yuan.,Luo,Ji-Feng.,Yan,Hui.,...&Wang,Yue-Hu.(2021).Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis..Natural products and bioprospecting,11(5),545-555.
MLA	Wei,Shu-Ya,et al."Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis.".Natural products and bioprospecting 11.5(2021):545-555.