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Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis.
Wei,Shu-Ya; Hu,Dong-Bao; Xia,Meng-Yuan; Luo,Ji-Feng; Yan,Hui; Yang,Jing-Hua; Wang,Yun-Song; Wang,Yue-Hu
2021
Source PublicationNatural products and bioprospecting
ISSN2192-2195
Volume11Issue:5Pages:545-555
AbstractOne novel spirolactone, aquilarisinolide (1), three new sesquiterpenoids, (2R,4S,5R,7R)-2-hydroxyeremophila-9,11-dien-8-one (2), (1R,4S,5S,7R,11R)-13-hydroxyepidaphnauran-9-en-8-one (3), and (4R,5S,7R,8S,10S,13R)-8,13-dihydroxyrotunda-1,11-dien-3-one (4), together with 13 known compounds (5-17) were isolated from the resinous heartwood of Aquilaria sinensis (Thymelaeaceae). The structures of the new compounds were elucidated based on the analysis of NMR and MS data and theoretical calculations their ECD spectra. The isolated compounds were evaluated for their protective activities against PC12 cell injury induced by corticosterone (CORT) and 1-methyl-4-phenylpyridine ion (MPP+), as well as inhibitory activities against BACE1. Compound 4, 5,6-dihydroxy-2-(2-phenylethyl)chromone (5), daphnauranol B (7), 6-methoxy-2-[2-(3-methyoxyphenyl)ethyl]chromone (10), isoagarotetrol (14), and 1-hydroxy-1,5-diphenylpentan-3-one (16) showed significant protective effects on CORT-induced injury in PC12 cells at a concentration of 20muM (P<0.001). Isoagarotetrol (14) showed a significant protective effect on MPP+-induced injury in PC12 cells at a concentration of 20muM (P<0.001), while compound 4 showed a moderate activity (P<0.01). The BACE1-inhibitory activities of all tested compounds were very weak with less than 30% inhibition at a concentration of 20muM.
DOI10.1007/s13659-021-00313-0
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73797
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Wei,Shu-Ya,Hu,Dong-Bao,Xia,Meng-Yuan,et al. Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis.[J]. Natural products and bioprospecting,2021,11(5):545-555.
APA Wei,Shu-Ya.,Hu,Dong-Bao.,Xia,Meng-Yuan.,Luo,Ji-Feng.,Yan,Hui.,...&Wang,Yue-Hu.(2021).Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis..Natural products and bioprospecting,11(5),545-555.
MLA Wei,Shu-Ya,et al."Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis.".Natural products and bioprospecting 11.5(2021):545-555.
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