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Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases
Arunachalm,Karuppusamy; Yang,Xuefei; San,Thae Thae
2022
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
Volume283Pages:114540
AbstractEthnopharmacological relevance: Tinospora cordifolia (Willd.) Miers (Menispermaceae) is a Mediterranean herb, used in Ayurvedic, Siddha, Unani, and folk medicines. The herb is also used in conventional medicine to treat oxidative stress-related diseases and conditions, including inflammation, pain, diarrhea, asthma, respiratory infections, cancer, diabetes, and gastrointestinal disorders.Aim of the review: The taxonomy, botanical classification, geographical distribution, and ethnobotanical uses of T. cordifolia, as well as the phytochemical compounds found in the herb, the toxicology of and pharmacological and clinical studies on the effects of T. cordifolia are all covered in this study.Materials and methods: To gather information on T. cordifolia, we used a variety of scientific databases, including Scopus, Google Scholar, PubMed, and Science Direct. The information discussed focuses on biologically active compounds found in T. cordifolia, and common applications and pharmacological activity of the herb, as well as toxicological and clinical studies on its properties.Results: The findings of this study reveal a connection between the use of T. cordifolia in conventional medicine and its antioxidant, anti-inflammatory, antihypertensive, antidiabetic, anticancer, immunomodulatory, and other biological effects. The entire plant, stem, leaves, root, and extracts of T. cordifolia have been shown to have a variety of biological activities, including antioxidant, antimicrobial, antiviral, antiparasitic, antidiabetic, anticancer, anti-inflammatory, analgesic and antipyretic, hepatoprotective, and cardioprotective impact. Toxicological testing demonstrated that this plant may have medicinal applications. T. cordifolia contains a variety of biologically active compounds from various chemical classes, including alkaloids, terpenoids, sitosterols, flavonoids, and phenolic acids. Based on the reports researched for this review, we believe that chemicals in T. cordifolia may activate Nrf2, which leads to the overexpression of antioxidant enzymes such as CAT, GPx, GST, and GR, and thereby induces the adaptive response to oxidative stress. T. cordifolia is also able to reduce NF-kappa B signalling by inhibiting PI3K/Akt, activating AMPK and sirtuins, and downregulating PI3K/Akt.Conclusions: Our findings indicate that the pharmacological properties displayed by T. cordifolia back up its conventional uses. Antimicrobial, antiviral, antioxidant, anticancer, anti-inflammatory, antimutagenic, antidiabetic, nephroprotective, gastroprotective, hepatoprotective, and cardioprotective activities were all demonstrated in T. cordifolia stem extracts. To validate pharmacodynamic targets, further research is needed to evaluate the molecular mechanisms of the known compounds against gastrointestinal diseases, inflammatory processes, and microbial infections, as immunostimulants, and in chemotherapy. The T. cordifolia safety profile was confirmed in a toxicological analysis, which prompted pharmacokinetic assessment testing to confirm its bioavailability.
KeywordTinospora cordifolia Traditional medicine Antioxidant Reactive oxygen species Immunomodulatory effect COVID-19 CLERODANE FURANO-DITERPENE INDIAN MEDICINAL-PLANTS IN-VITRO ANTIOXIDANT EX HOOK F FREE-RADICALS LIPID-PEROXIDATION ETHANOLIC EXTRACT AYURVEDIC FORMULATION ALCOHOLIC EXTRACT CARDIOPROTECTIVE ACTIVITY
DOI10.1016/j.jep.2021.114540
WOS IDWOS:000718033100003
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73789
Collection中国科学院昆明植物研究所
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
Recommended Citation
GB/T 7714
Arunachalm,Karuppusamy,Yang,Xuefei,San,Thae Thae. Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases[J]. JOURNAL OF ETHNOPHARMACOLOGY,2022,283:114540.
APA Arunachalm,Karuppusamy,Yang,Xuefei,&San,Thae Thae.(2022).Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases.JOURNAL OF ETHNOPHARMACOLOGY,283,114540.
MLA Arunachalm,Karuppusamy,et al."Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases".JOURNAL OF ETHNOPHARMACOLOGY 283(2022):114540.
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