Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2

doi:10.1007/s11418-021-01561-7

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	Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2
	Wang,Yajun ; Chang,Wenhui ; Li,Xuezheng ; Jiang,Zhe ; Zhou,Di ; Feng,Yuan ; Li,Bingxin ; Chen,Gang ; Li,Ning
	2022
发表期刊	JOURNAL OF NATURAL MEDICINES
ISSN	1340-3443
卷号	76 期号:1 页码:119-131
摘要	Apigenin (APG) is a flavonoid widely distributed in fruits, vegetables, and herbs, with comprehensive pharmacological effects. In this paper, we report that APG can elicit a protective effect, which is comparable to those induced by gymnoside II/n-BuOH extracts of Bletilla striata, on SiO2-induced lung injury in vitro and in vivo. In vitro experiments showed that APG (25 mu M) could restore the SiO2-decreased A549 cell viability and lower the apoptotic rate and the production of intracellular reactive oxygen species (ROS) in A549 cells treated with nm SiO2. Western blot results showed that APG (25 mu M) could increase the level of Nuclear factor E2-related factor 2 (Nrf2) and its downstream proteins. In vivo experiments showed that APG (20 mg/kg) could potently alleviate the SiO2-elicited lung injury by enhancing the Nrf2 expression and thereby suppressing Bax/Bcl-2 pathway. The present study suggests that APG can significantly alleviate the SiO2-induced lung injury both in vitro and in vivo through, at least partially, activating Nrf2 expression.[GRAPHICS].
关键词	APG Lung injury Nm SiO2 Nrf2 Chemoprevention OCCUPATIONAL SILICA EXPOSURE OXIDATIVE STRESS PARTICULATE MATTER INDUCED APOPTOSIS CELL-LINE CANCER PROTECTS NEUROPROTECTION INFLAMMATION TOXICITY
DOI	10.1007/s11418-021-01561-7
WOS记录号	WOS:000692437700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73759
专题	中国科学院昆明植物研究所
作者单位	1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China 2.Yanbian Univ Hosp, Dept PIVAS, Yanji, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Beijing, Peoples R China 4.Guangxi Normal Univ, Sate Key Lab Chem & Mol Engn Med Resources, Guilin, Guangxi, Peoples R China
推荐引用方式 GB/T 7714	Wang,Yajun,Chang,Wenhui,Li,Xuezheng,et al. Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2[J]. JOURNAL OF NATURAL MEDICINES,2022,76(1):119-131.
APA	Wang,Yajun.,Chang,Wenhui.,Li,Xuezheng.,Jiang,Zhe.,Zhou,Di.,...&Li,Ning.(2022).Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2.JOURNAL OF NATURAL MEDICINES,76(1),119-131.
MLA	Wang,Yajun,et al."Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2".JOURNAL OF NATURAL MEDICINES 76.1(2022):119-131.