Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction

doi:10.1021/acs.orglett.1c03120

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	Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction
	Li,Tian-Ze ; Yang,Xiao-Tong ; Wang,Jin-Ping ; Geng,Chang-An ; Ma,Yun-Bao ; Su,Li-Hua ; Zhang,Xue-Mei ; Chen,Ji-Jun
	2021
Source Publication	ORGANIC LETTERS
ISSN	1523-7060
Volume	23 Issue:21 Pages:8380-8384
Abstract	The biomimetic synthesis of guaianolide dialers lavandiolides H, I, and K and artematrolide F containing a spirolactone moiety has been accomplished for the first time from naturally abundant arglabin in four to six steps with an overall yield up to 60%, and a series of natural product-like guaianolide dimers, trimer, and tetramer were also successfully synthesized. Notably, the trimeric compound exhibited antihepatoma cytotoxicity more potent than that of sorafenib with IC50 values of 6.2 mu M (HepG2), 6.8 mu M (Huh7), and 7.2 mu M (SK-HEP-1).
Keyword	TRIMERS
DOI	10.1021/acs.orglett.1c03120
WOS ID	WOS:000716793100052
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73752
Collection	中国科学院昆明植物研究所
Affiliation	1.[Li, Tian-Ze 2.Yang, Xiao-Tong 3.Wang, Jin-Ping 4.Geng, Chang-An 5.Ma, Yun-Bao 6.Su, Li-Hua 7.Zhang, Xue-Mei 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 9.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	Li,Tian-Ze,Yang,Xiao-Tong,Wang,Jin-Ping,et al. Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction[J]. ORGANIC LETTERS,2021,23(21):8380-8384.
APA	Li,Tian-Ze.,Yang,Xiao-Tong.,Wang,Jin-Ping.,Geng,Chang-An.,Ma,Yun-Bao.,...&Chen,Ji-Jun.(2021).Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction.ORGANIC LETTERS,23(21),8380-8384.
MLA	Li,Tian-Ze,et al."Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction".ORGANIC LETTERS 23.21(2021):8380-8384.

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