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Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction
Li,Tian-Ze; Yang,Xiao-Tong; Wang,Jin-Ping; Geng,Chang-An; Ma,Yun-Bao; Su,Li-Hua; Zhang,Xue-Mei; Chen,Ji-Jun
2021
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号23期号:21页码:8380-8384
摘要The biomimetic synthesis of guaianolide dialers lavandiolides H, I, and K and artematrolide F containing a spirolactone moiety has been accomplished for the first time from naturally abundant arglabin in four to six steps with an overall yield up to 60%, and a series of natural product-like guaianolide dimers, trimer, and tetramer were also successfully synthesized. Notably, the trimeric compound exhibited antihepatoma cytotoxicity more potent than that of sorafenib with IC50 values of 6.2 mu M (HepG2), 6.8 mu M (Huh7), and 7.2 mu M (SK-HEP-1).
关键词TRIMERS
DOI10.1021/acs.orglett.1c03120
WOS记录号WOS:000716793100052
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73752
专题中国科学院昆明植物研究所
作者单位1.[Li, Tian-Ze
2.Yang, Xiao-Tong
3.Wang, Jin-Ping
4.Geng, Chang-An
5.Ma, Yun-Bao
6.Su, Li-Hua
7.Zhang, Xue-Mei
8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
9.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Li,Tian-Ze,Yang,Xiao-Tong,Wang,Jin-Ping,et al. Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction[J]. ORGANIC LETTERS,2021,23(21):8380-8384.
APA Li,Tian-Ze.,Yang,Xiao-Tong.,Wang,Jin-Ping.,Geng,Chang-An.,Ma,Yun-Bao.,...&Chen,Ji-Jun.(2021).Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction.ORGANIC LETTERS,23(21),8380-8384.
MLA Li,Tian-Ze,et al."Biomimetic Synthesis of Lavandiolides H, I, and K and Artematrolide F via Diels-Alder Reaction".ORGANIC LETTERS 23.21(2021):8380-8384.
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