HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities

doi:10.1016/j.phytochem.2021.112673

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	HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities
	Li,Fang-Ru ; Liu,Lu ; Liu,Ya-Ping ; Wang,Jin-Tang ; Yang,Mei-Lian ; Khan,Afsar ; Qin,Xu-Jie ; Wang,Yu-Dan ; Cheng,Gui-Guang
	2021
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	184 页码:112673
摘要	The Melodinus species have been proved to be good resources of bisindole alkaloids. Six bisindole alkaloids were isolated from the leaves and stems of Melodinus cochinchinensis (Lour.) Merr. guided by HRESIMS data analysis. Among them, melokhanines K-M, epi-scandomelonine, and epi-scandomeline possessed aspidosperma-scandine skeleton linked by a C-C bond while meloyine II had a scandine-scandine skeleton. The structures were established by extensive spectroscopic analysis of their HRESIMS and NMR data. Melokhanines K-M were undescribed compounds, while epi-scandomelonine, epi-scandomeline and meloyine II were known compounds, which were reported from Melodinus species for the first time. The anti-inflammatory and cytotoxic activities of the isolates were also evaluated in vitro. Melokhanine K and meloyine II showed potent inhibitory activity on the production of nitric oxide, interleukin-6, and tumor necrosis factor-alpha in LPS-induced RAW 264.7 macrophages, whereas episcandomelonine and epi-scandomeline exhibited certain cytotoxic activity against MOLT-4 cells with IC50 values 5.2 and 1.5 mu M, respectively.
关键词	Melodinus cochinchinensis (Lour.) Merr. (Apocynaceae) melokhanines Bisindole alkaloids Anti-inflammatory Cytotoxicity MONOTERPENOID INDOLE ALKALOIDS CHEMISTRY FRUITS
DOI	10.1016/j.phytochem.2021.112673
WOS记录号	WOS:000631274200023
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73743
专题	中国科学院昆明植物研究所
作者单位	1.Kunming Univ Sci & Technol, Fac Agr & Food, Kunming 650500, Yunnan, Peoples R China 2.Yunnan Univ Chinese Med, Yunnan Prov Key Lab Mol Biol Sinomed, Kunming 650500, Yunnan, Peoples R China 3.COMSATS Univ Islamabad, Dept Chem, Abbottabad Campus, Abbottabad 22060, Pakistan 4.Yunnan Minzu Univ, Natl & Local Joint Engn Res Ctr Green Preparat Te, Kunming 650500, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li,Fang-Ru,Liu,Lu,Liu,Ya-Ping,et al. HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities[J]. PHYTOCHEMISTRY,2021,184:112673.
APA	Li,Fang-Ru.,Liu,Lu.,Liu,Ya-Ping.,Wang,Jin-Tang.,Yang,Mei-Lian.,...&Cheng,Gui-Guang.(2021).HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities.PHYTOCHEMISTRY,184,112673.
MLA	Li,Fang-Ru,et al."HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities".PHYTOCHEMISTRY 184(2021):112673.