Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr

doi:10.1021/acs.orglett.0c03460

KIB OpenIR

	Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr
	Tang,Xiao-Han ; Luo,Rong-Can ; Ye,Mao-Sen ; Tang,Hong-Yu ; Ma,Yuan-Liang ; Chen,Yan-Ni ; Wang,Xin-Meng ; Lu,Qing-Yun ; Liu,Shuai ; Li,Xiao-Nian ; Yan,Ying ; Yang,Jing; Ran,Xiao-Qian ; Fang,Xin ; Zhou,Yan ; Yao,Yong-Gang ; Di,Ying-Tong ; Hao,Xiao-Jiang
	2021
Source Publication	ORGANIC LETTERS
ISSN	1523-7060
Volume	23 Issue:2 Pages:262-267
Abstract	Harpertrioate A (1), an A, B,D-seco-limonoid with a rearranged ring B incorporating exocyclic C-30, was isolated from the EtOAc extract of Harrisonia perforata twigs. Its structure, including absolute configurations, was determined on the basis of spectroscopic data and X-ray crystallography. This compound exhibited biological activities against Alzheimer's disease by reducing A beta 42 and A beta 40 production and shifting APP processing toward nonamyloidogenic pathway. The effect of 1 on the A beta production was comparable to that of gemfibrozil.
Keyword	AMYLOID PRECURSOR PROTEIN INSULIN-DEGRADING ENZYME BETA-PROTEIN GEMFIBROZIL PREVENTION SECRETASE ADAM10 MEN
DOI	10.1021/acs.orglett.0c03460
WOS ID	WOS:000643163800003
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73722
Collection	中国科学院昆明植物研究所
Affiliation	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Engn, Kunming 650091, Yunnan, Peoples R China 3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool,Chinese Acad Sci & Yunnan Prov, KIZ CUHK Joint Lab Bioresources & Mol Res Common, Kunming 650223, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China 5.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China 6.Guizhou Med Univ, Guizhou Chem Drug Res & Dev Engn Tech Ctr, Guiyang 550004, Peoples R China 7.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 8.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Tang,Xiao-Han,Luo,Rong-Can,Ye,Mao-Sen,et al. Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr[J]. ORGANIC LETTERS,2021,23(2):262-267.
APA	Tang,Xiao-Han.,Luo,Rong-Can.,Ye,Mao-Sen.,Tang,Hong-Yu.,Ma,Yuan-Liang.,...&Hao,Xiao-Jiang.(2021).Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr.ORGANIC LETTERS,23(2),262-267.
MLA	Tang,Xiao-Han,et al."Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr".ORGANIC LETTERS 23.2(2021):262-267.

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