Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy

doi:10.1080/14786419.2021.1955881

KIB OpenIR

	Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy
	Yang,Bao-Jia ; Wang,Juan ; Zeng,Zheng-Quan ; Yang,Xu ; Huang,Ai-Ying ; Hao,Xiao-Jiang; Ding,Xiao ; Li,Shun-Lin
	2021
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
摘要	Fourteen sesquiterpene lactones were isolated from the whole plant of Carpesium abrotanoides L. Their structures were determined on the basis of comprehensive spectroscopic data analysis. All compounds were screened for their cytotoxic activity, and compound 6 showed the strongest activity (IC50 2.73 - 7.21 mu M) against five human cancer cell lines, including A549, HepG2, HCT116, MDA-MB-231, and CNE2. Compound 6 was further investigated. Compound 6 effectively induced G2/M cell cycle arrest and ROS accumulation in a dose-dependent manner, which further led to apoptosis in cancer cells. Interestingly, compounds 1 and 6 could also activate protective autophagy, which was reported for the first time in sesquiterpene isolated from Carpesium abrotanoides. In addition, compounds 1 and 6 could induce lysosomal biogenesis by 173.2% and 163.7%, respectively. In sum, sesquiterpene lactones from Carpesium abrotanoides could induce apoptosis and protective autophagy in cancer cells, which provide a serial of compounds with potential clinical applications.
关键词	Carpesium abrotanoides L sesquiterpene lactone autophagy lysosomal biogenesis cytotoxic activity
DOI	10.1080/14786419.2021.1955881
WOS记录号	WOS:000675701600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73720
专题	中国科学院昆明植物研究所
作者单位	1.[Yang, Bao-Jia 2.Wang, Juan 3.Zeng, Zheng-Quan 4.Yang, Xu 5.Huang, Ai-Ying 6.Hao, Xiao-Jiang 7.Ding, Xiao 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 9.Univ Chinese Acad Sci, Beijing, Peoples R China 10.[Wang, Juan 11.Shaanxi Normal Univ, Xian, Peoples R China
推荐引用方式 GB/T 7714	Yang,Bao-Jia,Wang,Juan,Zeng,Zheng-Quan,et al. Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy[J]. NATURAL PRODUCT RESEARCH,2021.
APA	Yang,Bao-Jia.,Wang,Juan.,Zeng,Zheng-Quan.,Yang,Xu.,Huang,Ai-Ying.,...&Li,Shun-Lin.(2021).Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy.NATURAL PRODUCT RESEARCH.
MLA	Yang,Bao-Jia,et al."Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy".NATURAL PRODUCT RESEARCH (2021).