Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity

doi:10.1016/j.phytochem.2020.112566

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	Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity
	Zhao,Qian ; Zhu,Wen-Tao ; Ding,Xiao ; Huo,Zong-Qing ; Donkor,Paul O.; Adelakun,Tiwalade A.; Hao,Xiao-Jiang; Zhang,Yu
	2021
Source Publication	PHYTOCHEMISTRY
ISSN	0031-9422
Volume	181 Pages:112566
Abstract	Fourteen undescribed monoterpenoid indole alkaloids, voacafrines A-N, along with 7 known monoterpenoid indole alkaloids were isolated from the seeds of Voacanga africana Stapf. Among them, voacafrines A-G were aspidosperma-aspidosperma type bisindole alkaloids, while voacafrines H-N were aspidosperma-type monomers. Their structures and absolute configurations were elucidated by a combination of NMR, MS, and ECD analyses. Voacafrines A-C were characterized by an acetonyl moiety at C-5', while voacafrine H possessed a methoxymethyl moiety at C-14 within aspidosperma-type alkaloids. The acetylcholinesterase (AChE) inhibitory activity and cytotoxicity of voacafrines A-N were evaluated. Voacafrines A-C and E-G were bisindole alkaloids that exhibited AChE inhibitory activity with IC50 values of 4.97-33.28 mu M, while voacafrines I and J were monomers that showed cytotoxicity against several human cancer cell lines with IC50 values of 4.45-7.49 mu M.
Keyword	Voacanga africana stapf Apocynaceae Monoterpenoid indole alkaloids Voacafrines A-N AChE inhibitory activity
DOI	10.1016/j.phytochem.2020.112566
WOS ID	WOS:000598977700033
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73719
Collection	中国科学院昆明植物研究所
Affiliation	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Donkor, Paul O.] Univ Ghana, Sch Pharm, Accra, Ghana 4.Adelakun, Tiwalade A.] Natl Inst Pharmaceut Res & Dev NIPRD, Med Chem & Qual Control Dept, Abuja, Nigeria
Recommended Citation GB/T 7714	Zhao,Qian,Zhu,Wen-Tao,Ding,Xiao,et al. Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity[J]. PHYTOCHEMISTRY,2021,181:112566.
APA	Zhao,Qian.,Zhu,Wen-Tao.,Ding,Xiao.,Huo,Zong-Qing.,Donkor,Paul O..,...&Zhang,Yu.(2021).Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity.PHYTOCHEMISTRY,181,112566.
MLA	Zhao,Qian,et al."Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity".PHYTOCHEMISTRY 181(2021):112566.

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