Tsaokols A and B, unusual flavanol-monoterpenoid hybrids as alpha-glucosidase inhibitors from Amomum tsao-ko

doi:10.1016/j.cclet.2020.08.050

KIB OpenIR

	Tsaokols A and B, unusual flavanol-monoterpenoid hybrids as alpha-glucosidase inhibitors from Amomum tsao-ko
	He,Xiao-Feng ; Chen,Ji-Jun; Li,Tian-Ze ; Hu,Jing ; Zhang,Xu-Ke ; Guo,Yuan-Qiang ; Zhang,Xue-Mei ; Geng,Chang-An
	2021
Source Publication	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
Volume	32 Issue:3 Pages:1202-1205
Abstract	Tsaokols A (1) and B (2), two complicated flavanol-monoterpenoid hybrids, were isolated from the dried fruits of Amomum tsao-ko under the guidance of LCMS and bioassay. Their structures were determined by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 shared a flavanol backbone fused with 5/7 and 5/6 bicyclic monoterpenoid scaffolds, which were biogenetically condensed by Michael addition and acetalization. Compounds 1 and 2 exhibited significant alpha-glucosidase inhibitory activity with IC50 values of 18.8 and 38.6 mu mol/L (acarbose, IC50 = 213 mu mol/L). Docking study supported the strong interactions of 1 and 2 bonding with enzyme by mainly hydrophobic and hydrogen-bond effects. Compounds 1 and 2 could be fast distinguished by the diagnostic ions at m/z 289 and 313 in negative MS2 experiments. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Keyword	Amomum tsao-ko Zingiberaceae Flavanol-monoterpenoid hybrids alpha-Glucosidase inhibitors ANTIOXIDANT ACTIVITY ESSENTIAL OIL CONSTITUENTS CREVOST
DOI	10.1016/j.cclet.2020.08.050
WOS ID	WOS:000642399500014
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73676
Collection	中国科学院昆明植物研究所
Affiliation	1.[He, Xiao-Feng 2.Chen, Ji-Jun 3.Li, Tian-Ze 4.Hu, Jing 5.Zhang, Xue-Mei 6.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 7.[Zhang, Xu-Ke 8.Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China 9.Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China 10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	He,Xiao-Feng,Chen,Ji-Jun,Li,Tian-Ze,et al. Tsaokols A and B, unusual flavanol-monoterpenoid hybrids as alpha-glucosidase inhibitors from Amomum tsao-ko[J]. CHINESE CHEMICAL LETTERS,2021,32(3):1202-1205.
APA	He,Xiao-Feng.,Chen,Ji-Jun.,Li,Tian-Ze.,Hu,Jing.,Zhang,Xu-Ke.,...&Geng,Chang-An.(2021).Tsaokols A and B, unusual flavanol-monoterpenoid hybrids as alpha-glucosidase inhibitors from Amomum tsao-ko.CHINESE CHEMICAL LETTERS,32(3),1202-1205.
MLA	He,Xiao-Feng,et al."Tsaokols A and B, unusual flavanol-monoterpenoid hybrids as alpha-glucosidase inhibitors from Amomum tsao-ko".CHINESE CHEMICAL LETTERS 32.3(2021):1202-1205.

Files in This Item:		Download All
File Name/Size	DocType	Version	Access	License
079-F01-023-2021-何小凤（688KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	View Download

File name:	079-F01-023-2021-何小凤-CCL.pdf
Format:	Adobe PDF

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院昆明植物研究所知识管理系统