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Two new cytotoxic cycloartane triterpenoids from Aphanamixis polystachya (Wall.) R. N. Parker
Wang,Yi-ting; Fan,Shi-rui; Cai,Jie-yun; Guo,Jing-jing; Zhang,Xin-fang; Yang,Bi-juan; Hao,Xiao-jiang; Chen,Duo-zhi
2021
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
AbstractTwo new cycloartane triterpenoids, (24 R)-cycloartane-3 beta,24,25,30-tetrol (1) and (24 R)-24,25,30-trihydroxy-9,19-cycloartane-3-one (2), along with three known compounds (3-5) were isolated from leaves and twigs of Aphanamixis polystachya. The new compounds were elucidated based on comprehensive spectroscopic analysis, including 1 D, 2 D NMR and HREIMS. The in vitro cytotoxic activities evaluation of five human cancer cell lines revealed that compound 1 exhibited cytotoxic activity on all of tested human cancer cell lines, while compound 2 only had specific activity on SMMC-7721 cell line.
KeywordCytotoxic cycloartane triterpenoid Aphanamixis polystachya LEAVES
DOI10.1080/14786419.2021.1906242
WOS IDWOS:000658923000001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73654
Collection中国科学院昆明植物研究所
Affiliation1.[Wang, Yi-ting
2.Fan, Shi-rui
3.Cai, Jie-yun
4.Guo, Jing-jing
5.Zhang, Xin-fang
6.Yang, Bi-juan
7.Hao, Xiao-jiang
8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
9.Yunnan Univ, Dept Chem Sci & Engn, Kunming, Yunnan, Peoples R China
10.Yunnan Tobacco Qual Supervis & Test Stn, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wang,Yi-ting,Fan,Shi-rui,Cai,Jie-yun,et al. Two new cytotoxic cycloartane triterpenoids from Aphanamixis polystachya (Wall.) R. N. Parker[J]. NATURAL PRODUCT RESEARCH,2021.
APA Wang,Yi-ting.,Fan,Shi-rui.,Cai,Jie-yun.,Guo,Jing-jing.,Zhang,Xin-fang.,...&Chen,Duo-zhi.(2021).Two new cytotoxic cycloartane triterpenoids from Aphanamixis polystachya (Wall.) R. N. Parker.NATURAL PRODUCT RESEARCH.
MLA Wang,Yi-ting,et al."Two new cytotoxic cycloartane triterpenoids from Aphanamixis polystachya (Wall.) R. N. Parker".NATURAL PRODUCT RESEARCH (2021).
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