Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells

doi:10.1080/14786419.2019.1603223

KIB OpenIR

	Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells
	Dong,Fa-Wu ; Li,Fang ; Ren,Jia-Jia ; Zhao,Cheng-Mei ; Diao,Hong-Li ; Li,Bao-Jing ; Li,Yan-Ping ; Hu,Jiang-Miao ; He,Hong-Ping
	2021
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	35 期号:5 页码:757-762
摘要	Two new sesquiterpenoids, including a kessane-type sesquiterpenoid (1) and one bisabolane derivative (2), together with fourteen known sesquiterpenoids (3-16), were isolated from the roots and rhizomes of Valeriana amurensis. The structures of new compounds were established on the basis of extensive spectroscopic analysis. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells. As a results, four compounds including 10-12 and 15 showed potent promoting effects at the concentration of 10 mu M on NGF-induced neurite outgrowth in PC12 cells with the differentiation rate of 11.84%, 12.21%, 13.77% and 12.16%, respectively.[GRAPHICS].
关键词	Valeriana amurensis sesquiterpenoids central nervous system PC12 cells NERVE GROWTH-FACTOR IRIDOID GLYCOSIDES
DOI	10.1080/14786419.2019.1603223
WOS记录号	WOS:000470405900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73650
专题	中国科学院昆明植物研究所
作者单位	1.[Dong, Fa-Wu 2.Li, Fang 3.Ren, Jia-Jia 4.Zhao, Cheng-Mei 5.Diao, Hong-Li 6.Li, Bao-Jing 7.Li, Yan-Ping 8.Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming, Yunnan, Peoples R China 9.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Dong,Fa-Wu,Li,Fang,Ren,Jia-Jia,et al. Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells[J]. NATURAL PRODUCT RESEARCH,2021,35(5):757-762.
APA	Dong,Fa-Wu.,Li,Fang.,Ren,Jia-Jia.,Zhao,Cheng-Mei.,Diao,Hong-Li.,...&He,Hong-Ping.(2021).Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells.NATURAL PRODUCT RESEARCH,35(5),757-762.
MLA	Dong,Fa-Wu,et al."Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells".NATURAL PRODUCT RESEARCH 35.5(2021):757-762.