New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth

doi:10.1016/j.fitote.2021.104875

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	New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth
	Qin,Jing ; Liao,Chao-Nan ; Chen,Wei-wei ; Li,Hong-you ; Su,Jia ; Wu,Xing-De ; He,Jiang-bo ; Zhang,Gao-hong
	2021
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	152 页码:104875
摘要	One new limonoid, named 19-hydroxy methyl isoobacunoate diosphenol (1); one new degraded limonoid, named 9 alpha-methoxyl dictamdiol (9); two new quinolone alkaloids, 1-methyl-3-[(7E,9E,12Z)-7,9,12-pentadecadienyl]-4(1H)-quinolone (11) and 1-methyl-3-[(7E,9E,11E)-7,9,11-pentadecadienyl]-4(1H)-quinolone (12), along with eight known compounds, evodol (2), 7 beta-acetoxy-5-epilimonin (3), rutaevine (4), 6 beta-acetoxy-5-epilimonin (5), limonin (6), obacunone (7), clauemargine L (8), hiiranlactone E (10) were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth.. Structures of the four new compounds were elucidated on the basis of extensive spectroscopic techniques, including 1D and 2D NMR techniques. Compounds 3, 5, 9, 11 and 12 showed obviously cytotoxic activity against six human tumor lines, while compounds 11, 12 displayed anti-platelet aggregation induced by ADP at 50 mu M and 100 mu M.
关键词	Limonoid Quinolone alkaloid Cytotoxic activity Anti-platelet aggregation Evodia rutaecarpa (Juss ) Benth FRUITS
DOI	10.1016/j.fitote.2021.104875
WOS记录号	WOS:000663829000012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73649
专题	中国科学院昆明植物研究所
作者单位	1.[Qin, Jing 2.Liao, Chao-Nan 3.Chen, Wei-wei 4.Li, Hong-you 5.He, Jiang-bo 6.Kunming Univ, Sch Med, Kunming, Yunnan, Peoples R China 7.[Su, Jia 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Qin,Jing,Liao,Chao-Nan,Chen,Wei-wei,et al. New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth[J]. FITOTERAPIA,2021,152:104875.
APA	Qin,Jing.,Liao,Chao-Nan.,Chen,Wei-wei.,Li,Hong-you.,Su,Jia.,...&Zhang,Gao-hong.(2021).New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth.FITOTERAPIA,152,104875.
MLA	Qin,Jing,et al."New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth".FITOTERAPIA 152(2021):104875.