New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth

doi:10.1016/j.fitote.2021.104875

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	New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth
	Qin,Jing ; Liao,Chao-Nan ; Chen,Wei-wei ; Li,Hong-you ; Su,Jia ; Wu,Xing-De ; He,Jiang-bo ; Zhang,Gao-hong
	2021
Source Publication	FITOTERAPIA
ISSN	0367-326X
Volume	152 Pages:104875
Abstract	One new limonoid, named 19-hydroxy methyl isoobacunoate diosphenol (1); one new degraded limonoid, named 9 alpha-methoxyl dictamdiol (9); two new quinolone alkaloids, 1-methyl-3-[(7E,9E,12Z)-7,9,12-pentadecadienyl]-4(1H)-quinolone (11) and 1-methyl-3-[(7E,9E,11E)-7,9,11-pentadecadienyl]-4(1H)-quinolone (12), along with eight known compounds, evodol (2), 7 beta-acetoxy-5-epilimonin (3), rutaevine (4), 6 beta-acetoxy-5-epilimonin (5), limonin (6), obacunone (7), clauemargine L (8), hiiranlactone E (10) were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth.. Structures of the four new compounds were elucidated on the basis of extensive spectroscopic techniques, including 1D and 2D NMR techniques. Compounds 3, 5, 9, 11 and 12 showed obviously cytotoxic activity against six human tumor lines, while compounds 11, 12 displayed anti-platelet aggregation induced by ADP at 50 mu M and 100 mu M.
Keyword	Limonoid Quinolone alkaloid Cytotoxic activity Anti-platelet aggregation Evodia rutaecarpa (Juss ) Benth FRUITS
DOI	10.1016/j.fitote.2021.104875
WOS ID	WOS:000663829000012
Citation statistics	Cited Times:12[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73649
Collection	中国科学院昆明植物研究所
Affiliation	1.[Qin, Jing 2.Liao, Chao-Nan 3.Chen, Wei-wei 4.Li, Hong-you 5.He, Jiang-bo 6.Kunming Univ, Sch Med, Kunming, Yunnan, Peoples R China 7.[Su, Jia 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Qin,Jing,Liao,Chao-Nan,Chen,Wei-wei,et al. New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth[J]. FITOTERAPIA,2021,152:104875.
APA	Qin,Jing.,Liao,Chao-Nan.,Chen,Wei-wei.,Li,Hong-you.,Su,Jia.,...&Zhang,Gao-hong.(2021).New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth.FITOTERAPIA,152,104875.
MLA	Qin,Jing,et al."New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth".FITOTERAPIA 152(2021):104875.

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