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The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD(+) levels
Fang,Chengchi; Gan,Xiaoni; Zhang,Chengjun; He,Shunping
2021
发表期刊SCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
卷号64期号:11页码:1929-1948
摘要The origination of new genes is important for generating genetic novelties for adaptive evolution and biological diversity. However, their potential roles in embryonic development, evolutionary processes into ancient networks, and contributions to adaptive evolution remain poorly investigated. Here, we identified a novel chimeric gene family, the chiron family, and explored its genetic basis and functional evolution underlying the adaptive evolution of Danioninae fishes. The ancestral chiron gene originated through retroposition of nampt in Danioninae 48-54 million years ago (Mya) and expanded into five duplicates (chiron1-5) in zebrafish 1-4 Mya. The chiron genes (chirons) likely originated in embryonic development and gradually extended their expression in the testis. Functional experiments showed that chirons were essential for zebrafish embryo development. By integrating into the NAD(+) synthesis pathway, chirons could directly catalyze the NAD(+) rate-limiting reaction and probably impact two energy metabolism genes (nmnat1 and naprt) to be under positive selection in Danioninae fishes. Together, these results mainly demonstrated that the origin of new chimeric chiron genes may be involved in adaptive evolution by integrating and impacting the NAD(+) biosynthetic pathway. This coevolution may contribute to the physiological adaptation of Danioninae fishes to widespread and varied biomes in Southeast Asian.
关键词new chimeric genes essential function NAD plus rate-limiting enzyme coevolution COLONY-ENHANCING FACTOR DE-NOVO ORIGINATION PHYLOGENETIC ANALYSIS PROTEIN DIVERSITY RAPID EVOLUTION DUPLICATE GENES GENERATION TIME PATHWAY YOUNG NEOFUNCTIONALIZATION
DOI10.1007/s11427-020-1851-0
WOS记录号WOS:000613335800005
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73647
专题中国科学院昆明植物研究所
作者单位1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
5.Huazhong Agr Univ, Wuhan 430070, Peoples R China
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Fang,Chengchi,Gan,Xiaoni,Zhang,Chengjun,et al. The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD(+) levels[J]. SCIENCE CHINA-LIFE SCIENCES,2021,64(11):1929-1948.
APA Fang,Chengchi,Gan,Xiaoni,Zhang,Chengjun,&He,Shunping.(2021).The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD(+) levels.SCIENCE CHINA-LIFE SCIENCES,64(11),1929-1948.
MLA Fang,Chengchi,et al."The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD(+) levels".SCIENCE CHINA-LIFE SCIENCES 64.11(2021):1929-1948.
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