Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases

doi:10.1021/acs.jnatprod.0c01101

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	Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases
	Ren,Fu-Cai ; Liu,Li; Lv,Yong-Feng ; Bai,Xue ; Kang,Qian-Jin ; Hu,Xiao-Jing ; Zhuang,Hong-Dan ; Yang,Liu ; Hu,Jiang-Miao ; Zhou,Jun
	2021
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	84 期号:2 页码:417-426
摘要	Twelve hitherto unknown tandem prenylated p-hydroxybenzoic acid derivatives, namely, oberoniamyosurusins A-L, together with five known derivatives, were isolated from an EtOH extract of the whole parts of the plant Oberonia myosurus. Compounds 10, 13, and 17 exhibited moderate inhibitory activity against Staphylococcus aureus subsp. aureus ATCC29213 with MIC50 values ranging from 7.6 to 23 mu g/mL. To determine the biosynthetic pathway of this class of tandem prenyl-substituted compounds, the full-length transcriptome of O. myosurus was sequenced, yielding 19.09 Gb of clean data and 10 949 nonredundant sequences. Two isoforms of p-hydroxybenzoic acid prenyltransferases were annotated and functionally characterized as the enzymes that might be involved in the biosynthesis of nervogenic acid (13) in Pichia pastoris.
DOI	10.1021/acs.jnatprod.0c01101
WOS记录号	WOS:000624549800023
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73639
专题	中国科学院昆明植物研究所
作者单位	1.[Ren, Fu-Cai 2.Liu, Li 3.Lv, Yong-Feng 4.Bai, Xue 5.Zhuang, Hong-Dan 6.Yang, Liu 7.Hu, Jiang-Miao 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 9.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 11.[Kang, Qian-Jin 12.Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China 13.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Ren,Fu-Cai,Liu,Li,Lv,Yong-Feng,et al. Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(2):417-426.
APA	Ren,Fu-Cai.,Liu,Li.,Lv,Yong-Feng.,Bai,Xue.,Kang,Qian-Jin.,...&Zhou,Jun.(2021).Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases.JOURNAL OF NATURAL PRODUCTS,84(2),417-426.
MLA	Ren,Fu-Cai,et al."Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases".JOURNAL OF NATURAL PRODUCTS 84.2(2021):417-426.

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