Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases

doi:10.1021/acs.jnatprod.0c01101

KIB OpenIR

	Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases
	Ren,Fu-Cai ; Liu,Li; Lv,Yong-Feng ; Bai,Xue ; Kang,Qian-Jin ; Hu,Xiao-Jing ; Zhuang,Hong-Dan ; Yang,Liu ; Hu,Jiang-Miao ; Zhou,Jun
	2021
Source Publication	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
Volume	84 Issue:2 Pages:417-426
Abstract	Twelve hitherto unknown tandem prenylated p-hydroxybenzoic acid derivatives, namely, oberoniamyosurusins A-L, together with five known derivatives, were isolated from an EtOH extract of the whole parts of the plant Oberonia myosurus. Compounds 10, 13, and 17 exhibited moderate inhibitory activity against Staphylococcus aureus subsp. aureus ATCC29213 with MIC50 values ranging from 7.6 to 23 mu g/mL. To determine the biosynthetic pathway of this class of tandem prenyl-substituted compounds, the full-length transcriptome of O. myosurus was sequenced, yielding 19.09 Gb of clean data and 10 949 nonredundant sequences. Two isoforms of p-hydroxybenzoic acid prenyltransferases were annotated and functionally characterized as the enzymes that might be involved in the biosynthesis of nervogenic acid (13) in Pichia pastoris.
DOI	10.1021/acs.jnatprod.0c01101
WOS ID	WOS:000624549800023
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73639
Collection	中国科学院昆明植物研究所
Affiliation	1.[Ren, Fu-Cai 2.Liu, Li 3.Lv, Yong-Feng 4.Bai, Xue 5.Zhuang, Hong-Dan 6.Yang, Liu 7.Hu, Jiang-Miao 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 9.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 11.[Kang, Qian-Jin 12.Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China 13.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
Recommended Citation GB/T 7714	Ren,Fu-Cai,Liu,Li,Lv,Yong-Feng,et al. Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(2):417-426.
APA	Ren,Fu-Cai.,Liu,Li.,Lv,Yong-Feng.,Bai,Xue.,Kang,Qian-Jin.,...&Zhou,Jun.(2021).Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases.JOURNAL OF NATURAL PRODUCTS,84(2),417-426.
MLA	Ren,Fu-Cai,et al."Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases".JOURNAL OF NATURAL PRODUCTS 84.2(2021):417-426.

Files in This Item:		Download All
File Name/Size	DocType	Version	Access	License
096-G09-060-胡-JNP.pd（2521KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	View Download

File name:	096-G09-060-胡-JNP.pdf
Format:	Adobe PDF

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院昆明植物研究所知识管理系统