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Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases
Ren,Fu-Cai; Liu,Li; Lv,Yong-Feng; Bai,Xue; Kang,Qian-Jin; Hu,Xiao-Jing; Zhuang,Hong-Dan; Yang,Liu; Hu,Jiang-Miao; Zhou,Jun
2021
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume84Issue:2Pages:417-426
AbstractTwelve hitherto unknown tandem prenylated p-hydroxybenzoic acid derivatives, namely, oberoniamyosurusins A-L, together with five known derivatives, were isolated from an EtOH extract of the whole parts of the plant Oberonia myosurus. Compounds 10, 13, and 17 exhibited moderate inhibitory activity against Staphylococcus aureus subsp. aureus ATCC29213 with MIC50 values ranging from 7.6 to 23 mu g/mL. To determine the biosynthetic pathway of this class of tandem prenyl-substituted compounds, the full-length transcriptome of O. myosurus was sequenced, yielding 19.09 Gb of clean data and 10 949 nonredundant sequences. Two isoforms of p-hydroxybenzoic acid prenyltransferases were annotated and functionally characterized as the enzymes that might be involved in the biosynthesis of nervogenic acid (13) in Pichia pastoris.
DOI10.1021/acs.jnatprod.0c01101
WOS IDWOS:000624549800023
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73639
Collection中国科学院昆明植物研究所
Affiliation1.[Ren, Fu-Cai
2.Liu, Li
3.Lv, Yong-Feng
4.Bai, Xue
5.Zhuang, Hong-Dan
6.Yang, Liu
7.Hu, Jiang-Miao
8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
9.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
11.[Kang, Qian-Jin
12.Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China
13.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
Recommended Citation
GB/T 7714
Ren,Fu-Cai,Liu,Li,Lv,Yong-Feng,et al. Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(2):417-426.
APA Ren,Fu-Cai.,Liu,Li.,Lv,Yong-Feng.,Bai,Xue.,Kang,Qian-Jin.,...&Zhou,Jun.(2021).Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases.JOURNAL OF NATURAL PRODUCTS,84(2),417-426.
MLA Ren,Fu-Cai,et al."Antibacterial Prenylated p-Hydroxybenzoic Acid Derivatives from Oberonia myosurus and Identification of Putative Prenyltransferases".JOURNAL OF NATURAL PRODUCTS 84.2(2021):417-426.
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