Nine Unique Iridoids and Iridoid Glycosides From Patrinia scabiosaefolia
Liu,Zhenhua; Niu,Yun; Zhou,Li; Meng,Lijun; Chen,Sitan; Wang,Mengke; Hu,Jiangmiao; Kang,Wenyi
AbstractPatrinia scabiosaefolia is a medical and edible Chinese herb with high nutritional and medicinal value. The continuing study of its chemical constituents led to the discovery of nine unique iridoids and iridoid glycosides, including three new iridoids (1-3) and six previously unknown irioid glycosides (5-10), and one known compound (4). Among them, compound 1 was a deformed iridoid, while compounds 3, 5-7, and 10 formed a new ring in their skeletons which was uncommon in this genus. For compound 3, the new ring existed between C-3 and C-10, while a 1,3-dioxane appeared between C-7 and C-10 in compounds 5-7 and 10. Moreover, compound 10 was a bis-iridoid glycoside, which was the first reported in P. scabiosaefolia. And the sugar of irioid glycosides (5-10) was glucose at C-11, except in 9 which had a 5-deoxyglucose moiety. All their structures were confirmed based on the extensive spectroscopic analysis, including IR, UV, HR-ESI-MS, ECD, and 1D- and 2D-NMR experiments. Their cytotoxic activities against HL-60, A-549, SMMC-7721, MCF-7, SW480 were also tested.
KeywordPatrinia scabiosaefolia iridoid iridoid glycoside bis-iridoid glycoside cytotoxic activity
WOS IDWOS:000639015600001
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Document Type期刊论文
Affiliation1.Henan Univ, Natl Ctr Res & Dev Edible Fungus Proc Technol, Kaifeng, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
4.Henan Univ, Joint Int Res Lab Food & Med Resource Funct, Kaifeng, Peoples R China
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Liu,Zhenhua,Niu,Yun,Zhou,Li,et al. Nine Unique Iridoids and Iridoid Glycosides From Patrinia scabiosaefolia[J]. FRONTIERS IN CHEMISTRY,2021,9:657028.
APA Liu,Zhenhua.,Niu,Yun.,Zhou,Li.,Meng,Lijun.,Chen,Sitan.,...&Kang,Wenyi.(2021).Nine Unique Iridoids and Iridoid Glycosides From Patrinia scabiosaefolia.FRONTIERS IN CHEMISTRY,9,657028.
MLA Liu,Zhenhua,et al."Nine Unique Iridoids and Iridoid Glycosides From Patrinia scabiosaefolia".FRONTIERS IN CHEMISTRY 9(2021):657028.
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