Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum

doi:10.1016/j.phytochem.2021.112780

KIB OpenIR

	Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum
	Guo,Kai ; Liu,Yan-Chun ; Liu,Yan ; Zhang,Han ; Li,Wen-Yuan ; Shi,Qiu-Mei ; Li,Xiao-Nian ; Zeng,Fang ; Li,Sheng-Hong
	2021
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	187 页码:112780
摘要	Whole plants of Gentianella turkestanorum are commonly used as a traditional Uighur medicine. A phytochemical investigation led to the isolation of eight undescribed gentianellane-type sesterterpenoids (18-epi-nitidasin, gentianelloids D-F, and 18-epi-gentianelloids C-F), one undescribed 11,12-seco-gentianellane (18-epi-alborosin), and three known analogs (nitidasin, gentianelloid C and alborosin) among which gentianelloid C was found for the first time from a natural source. The structures of these compounds were elucidated by extensive spectroscopic analyses (including 1D and 2D NMR, HRMS, IR, and specific rotation) and in the case of 18-epi-gentianelloid C by the single-crystal X-ray diffraction analysis. A putative biosynthetic route for these sesterterpenoids was proposed. The immunosuppressive activity of the isolated compounds was also evaluated by their ability to inhibit the proliferation of T cells and T cell cytokine IFN-gamma production. Nitidasin suppressed IFN-gamma production with an IC50 value of 16.50 mu M, while gentianelloid F and alborosin inhibited the proliferation of and IFN-gamma production in T cells with IC50 values of 12.40-14.66 mu M.
关键词	Gentianella turkestanorum Gentianaceae Plant sesterterpenoids Gentianellane-type Immunosuppressive activity GLANDULAR TRICHOMES LEUCOSCEPTRUM-CANUM CONSTITUENTS PRODUCTS HARBOR
DOI	10.1016/j.phytochem.2021.112780
WOS记录号	WOS:000654130400029
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73518
专题	中国科学院昆明植物研究所
作者单位	1.[Guo, Kai 2.Liu, Yan 3.Zeng, Fang 4.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 5.[Liu, Yan-Chun 6.Zhang, Han 7.Li, Wen-Yuan 8.Li, Xiao-Nian 9.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 10.Wuyi Univ, Coll Tea & Food Technol, Wuyishan 354300, Peoples R China
推荐引用方式 GB/T 7714	Guo,Kai,Liu,Yan-Chun,Liu,Yan,et al. Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum[J]. PHYTOCHEMISTRY,2021,187:112780.
APA	Guo,Kai.,Liu,Yan-Chun.,Liu,Yan.,Zhang,Han.,Li,Wen-Yuan.,...&Li,Sheng-Hong.(2021).Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum.PHYTOCHEMISTRY,187,112780.
MLA	Guo,Kai,et al."Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum".PHYTOCHEMISTRY 187(2021):112780.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
049-D10-084-黎-Phytoc（3245KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载