The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis

doi:10.1039/d1np00021g

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	The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis
	Guo,Kai ; Liu,Yan ; Li,Sheng-Hong
	2021
发表期刊	NATURAL PRODUCT REPORTS
ISSN	0265-0568
卷号	38 期号:12 页码:2293-2314
摘要	Covering: 1969 up to 2021Sesterterpenoids, biosynthetically derived from the precursor, namely geranylfarnesyl diphosphate (GFDP) are amongst the rarest of all isoprenoids with approximately 1300 compounds known. Most sesterterpenoids originate from marine organisms (especially sponges), while only about 15% of these compounds are isolated from several families of plants such as Lamiaceae, Gentianaceae, and Nartheciaceae. Many plant sesterterpenoids possess highly oxygenated and complex cyclic skeletons and exhibit remarkable biological activities involving cytotoxic, anti-inflammatory, antimicrobial, and antifeedant properties. Thus, due to their intrinsic chemical complexity and intriguing biological profiles, plant sesterterpenoids have attracted continuing interest from both chemists and biologists. However, the biosynthesis and distribution of sesterterpenoids in the plant kingdom still remain elusive, although substantial progress has been achieved in recent years. This review provides an overall coverage of sesterterpenoids originating from plant sources, followed by a classification of their chemical skeletons, which summarizes the distribution, chemistry, biological activities, biosynthesis and evolution of plant sesterterpenoids, aiming at strengthening the research efforts toward the untapped great potential of these unique natural product resources.
关键词	LEUCOSCEPTRUM-CANUM GLANDULAR TRICHOMES FERN CONSTITUENTS AERIAL PARTS ABSOLUTE STEREOCHEMISTRY SALVIA CYCLIZATION SYNTHASES NORSESTERTERPENES CONFIGURATION
DOI	10.1039/d1np00021g
WOS记录号	WOS:000660103800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73517
专题	中国科学院昆明植物研究所
作者单位	1.[Guo, Kai 2.Liu, Yan 3.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 4.[Liu, Yan 5.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Guo,Kai,Liu,Yan,Li,Sheng-Hong. The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis[J]. NATURAL PRODUCT REPORTS,2021,38(12):2293-2314.
APA	Guo,Kai,Liu,Yan,&Li,Sheng-Hong.(2021).The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis.NATURAL PRODUCT REPORTS,38(12),2293-2314.
MLA	Guo,Kai,et al."The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis".NATURAL PRODUCT REPORTS 38.12(2021):2293-2314.

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