Leucoabietenes A and B, rearranged abietane and ent-abietane diterpene hydrocarbons against resistant infectious fungus and bacterium from the leaves of Leucosceptrum canum

doi:10.1016/j.tetlet.2021.153356

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	Leucoabietenes A and B, rearranged abietane and ent-abietane diterpene hydrocarbons against resistant infectious fungus and bacterium from the leaves of Leucosceptrum canum
	Zhang,Man-Wen ; Guo,Kai ; Zhang,Yu; Teng,Lin-Lin ; Huang,Qing-Pu ; Liu,Yan ; Li,Sheng-Hong
	2021
发表期刊	TETRAHEDRON LETTERS
ISSN	0040-4039
卷号	81 页码:153356
摘要	Two new rearranged abietane and ent-abietane diterpene hydrocarbons, leucoabietenes A (1) and B (2) were isolated from the non-polar portion of the leaves of Leucosceptrum canum. Their structures were determined by various spectroscopic methods (including 1D and 2D NMR, HRMS, IR, and ECD), and in the case of 1 by the calculated ECD method. Biological assays indicated that compound 1 significantly reversed the antifungal activity of fluconazole against fluconazole-resistant Candida albicans (inhibitory rate >88%) with concentrations more than 32 mu g/mL, and compound 2 exhibited moderate inhibitory effect against methicillin-resistant Staphylococcus aureus. (C) 2021 Elsevier Ltd. All rights reserved.
关键词	Leucosceptrum canum Ent-abietane diterpene Abietane diterpene Antimicrobial activity TERPENOIDS
DOI	10.1016/j.tetlet.2021.153356
WOS记录号	WOS:000709773200004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73513
专题	中国科学院昆明植物研究所
作者单位	1.[Zhang, Man-Wen 2.Zhang, Yu 3.Teng, Lin-Lin 4.Huang, Qing-Pu 5.Liu, Yan 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 7.[Guo, Kai 8.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 9.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 10.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhang,Man-Wen,Guo,Kai,Zhang,Yu,et al. Leucoabietenes A and B, rearranged abietane and ent-abietane diterpene hydrocarbons against resistant infectious fungus and bacterium from the leaves of Leucosceptrum canum[J]. TETRAHEDRON LETTERS,2021,81:153356.
APA	Zhang,Man-Wen.,Guo,Kai.,Zhang,Yu.,Teng,Lin-Lin.,Huang,Qing-Pu.,...&Li,Sheng-Hong.(2021).Leucoabietenes A and B, rearranged abietane and ent-abietane diterpene hydrocarbons against resistant infectious fungus and bacterium from the leaves of Leucosceptrum canum.TETRAHEDRON LETTERS,81,153356.
MLA	Zhang,Man-Wen,et al."Leucoabietenes A and B, rearranged abietane and ent-abietane diterpene hydrocarbons against resistant infectious fungus and bacterium from the leaves of Leucosceptrum canum".TETRAHEDRON LETTERS 81(2021):153356.

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