Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis

doi:10.1021/acs.joc.1c00374

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	Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis
	Jing,Shu-Xi ; Fu,Ran ; Li,Chun-Huan ; Zhou,Ting-Ting ; Liu,Yan-Chun ; Liu,Yan ; Luo,Shi-Hong ; Li,Xiao-Nian ; Zeng,Fang ; Li,Sheng-Hong
	2021
发表期刊	JOURNAL OF ORGANIC CHEMISTRY
ISSN	0022-3263
卷号	86 期号:16 页码:11169-11176
摘要	A pair of new C-14 epimeric sesterterpenoids, colquhounoid D (1) and 14-epi-colquhounoid D (2), and five degradation products featuring new C-20 and C-21 frameworks, norcolquhounoids A-E (3-7), were isolated from Colquhounia coccinea var. mollis. Their structures were elucidated by comprehensive spectroscopic analysis and single-crystal X-ray diffraction. Degradation of the C-25 skeleton to the C-21 skeleton was also achieved using aqueous NaIO4 and RuCl3. Compounds 1 and 2 showed significant immunosuppressive activity on the cytokine IFN-gamma secretion of mouse splenocytes induced by anti-CD3/CD4 monoclonal antibodies, with IC50 of 8.38 and 5.79 mu M, respectively, and compounds 5 and 6 were moderately active.
关键词	LEUCOSCEPTRUM-CANUM GLANDULAR TRICHOMES PRODUCTS FAMILY HARBOR
DOI	10.1021/acs.joc.1c00374
WOS记录号	WOS:000687851300023
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73510
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Sch, Teaching Hosp 3, Chengdu 611137, Peoples R China 5.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 6.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China
推荐引用方式 GB/T 7714	Jing,Shu-Xi,Fu,Ran,Li,Chun-Huan,et al. Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(16):11169-11176.
APA	Jing,Shu-Xi.,Fu,Ran.,Li,Chun-Huan.,Zhou,Ting-Ting.,Liu,Yan-Chun.,...&Li,Sheng-Hong.(2021).Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis.JOURNAL OF ORGANIC CHEMISTRY,86(16),11169-11176.
MLA	Jing,Shu-Xi,et al."Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis".JOURNAL OF ORGANIC CHEMISTRY 86.16(2021):11169-11176.

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