KIB OpenIR
Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, accepted inhibits colorectal cancer stem cell growth
He,YingYing; Liu,Shubai; Newburg,David S.
2021
发表期刊BIOMEDICINE & PHARMACOTHERAPY
ISSN0753-3322
卷号144页码:112339
摘要Colorectal cancer is the second deadly cancer in the world. Trametes versicolor is a traditional Chinese medicinal mushroom with a long history of being used to regulate immunity and prevent cancer. Trametes versicolor mushroom extract demonstrates strongly cell growth inhibitory activity on human colorectal tumor cells. In this study, we characterized a novel 12-kDa protein that named musarin, which was purified from Trametes versicolor mushroom extract and showed significant growth inhibition on multiple human colorectal cancer cell lines in vitro. The protein sequence of musarin was determined through enzyme digestion and MS/MS analysis. Furthermore, Musarin, in particular, strongly inhibits aggressive human colorectal cancer stem cell-like CD24(+)CD44(+) HT29 proliferation in vitro and in a NOD/SCID murine xenograft model. Through whole transcription profile and gene enrichment analysis of musarin-treated CSCs-like cells, major signaling pathways and network modulated by musarin have been enriched, including the bioprocess of the Epithelial-Mesenchymal Transition, the EGFR-Ras signaling pathway and enzyme inhibitor activity. Musarin demonstrated tyrosine kinase inhibitory activity in vitro. Musarin strongly attenuated EGFR expression and down-regulated phosphorylation level, thereby slowing cancer cells proliferation. In addition, oral ingestion of musarin significantly inhibited CD24(+)CD44(+) HT29 generated tumor development in SCID/NOD mice with less side effects in microgram doses. Targeting self-renewal aggressive stem-cell like cancer cell proliferation, with higher water solubility and lower cytotoxicity, musarin has shown strong potence to be developed as a promising novel therapeutic drug candidate against colorectal cancers, especially those that acquire chemo-resistance.
关键词Trametes versicolor Cancer stem cell Tyrosine kinase inhibitor EGFR Colorectal cancer FACTOR RECEPTOR POLYSACCHAROPEPTIDE RESISTANCE TARGET EGFR TOOL PSP DNA
DOI10.1016/j.biopha.2021.112339
WOS记录号WOS:000712624000003
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73458
专题中国科学院昆明植物研究所
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Blue Black St, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
3.Newburg, David S.] Univ Cincinnati, Coll Med, 130 Panzeca Way, Cincinnati, OH 45267 USA
推荐引用方式
GB/T 7714
He,YingYing,Liu,Shubai,Newburg,David S.. Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, accepted inhibits colorectal cancer stem cell growth[J]. BIOMEDICINE & PHARMACOTHERAPY,2021,144:112339.
APA He,YingYing,Liu,Shubai,&Newburg,David S..(2021).Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, accepted inhibits colorectal cancer stem cell growth.BIOMEDICINE & PHARMACOTHERAPY,144,112339.
MLA He,YingYing,et al."Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, accepted inhibits colorectal cancer stem cell growth".BIOMEDICINE & PHARMACOTHERAPY 144(2021):112339.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
109-H08-110-musarin.(4251KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[He,YingYing]的文章
[Liu,Shubai]的文章
[Newburg,David S.]的文章
百度学术
百度学术中相似的文章
[He,YingYing]的文章
[Liu,Shubai]的文章
[Newburg,David S.]的文章
必应学术
必应学术中相似的文章
[He,YingYing]的文章
[Liu,Shubai]的文章
[Newburg,David S.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 109-H08-110-musarin.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。