Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy

doi:10.3390/ijms222313116

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	Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy
	Chen,Cheng ; Tian,Jiao ; He,Zhicheng ; Xiong,Wenyong; He,Yingying ; Liu,Shubai
	2021
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1422-0067
卷号	22 期号:23 页码:13116
摘要	Ischemic cardiomyopathy is the most frequent type of heart disease, and it is a major cause of myocardial infarction (MI) and heart failure (HF), both of which require expensive medical treatment. Precise biomarkers and therapy targets must be developed to enhance improve diagnosis and treatment. In this study, the transcriptional profiles of 313 patients' left ventricle biopsies were obtained from the PubMed database, and functional genes that were significantly related to ischemic cardiomyopathy were screened using the Weighted Gene Co-Expression Network Analysis and protein-protein interaction (PPI) networks enrichment analysis. The rat myocardial infarction model was developed to validate these findings. Finally, the putative signature genes were blasted through the common Cardiovascular Disease Knowledge Portal to explore if they were associated with cardiovascular disorder. Three interferon stimulated genes (IFIT2, IFIT3 and IFI44L), as well as key pathways, have been identified as potential biomarkers and therapeutic targets for ischemic cardiomyopathy, and their alternations or mutations have been proven to be strongly linked to cardiac disorders. These novel signature genes could be utilized as bio-markers or potential therapeutic objectives in precise clinical diagnosis and treatment of ischemic cardiomyopathy.
关键词	ischemic cardiomyopathy heart failure WGCNA interferon stimulated genes IFIT2 3 MYOCARDIAL-INFARCTION NETWORK ANALYSIS GENE
DOI	10.3390/ijms222313116
WOS记录号	WOS:000735646700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73455
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yunnan Univ, Sch Life Sci, Kunming 650091, Yunnan, Peoples R China 4.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Chen,Cheng,Tian,Jiao,He,Zhicheng,et al. Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021,22(23):13116.
APA	Chen,Cheng,Tian,Jiao,He,Zhicheng,Xiong,Wenyong,He,Yingying,&Liu,Shubai.(2021).Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(23),13116.
MLA	Chen,Cheng,et al."Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22.23(2021):13116.

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