Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives

doi:10.3390/molecules26113249

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	Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives
	Luo,Han ; Lv,Yong-Feng ; Zhang,Hong ; Hu,Jiang-Miao ; Li,Hong-Mei ; Liu,Shou-Jin
	2021
发表期刊	MOLECULES
ISSN	1420-3049
卷号	26 期号:11 页码:3249
摘要	A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.
关键词	mollugin triazoles antitumor activity synthesis ANTIMICROBIAL ACTIVITY RUBIA-CORDIFOLIA MOLLUGIN DESIGN ANALOGS BIOEVALUATION GLYCOSIDES APOPTOSIS AZIDES
DOI	10.3390/molecules26113249
WOS记录号	WOS:000660474600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73454
专题	中国科学院昆明植物研究所
作者单位	1.[Luo, Han 2.Zhang, Hong 3.Anhui Univ Chinese Med, Coll Pharm, Hefei 230011, Peoples R China 4.[Lv, Yong-Feng 5.Hu, Jiang-Miao 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Luo,Han,Lv,Yong-Feng,Zhang,Hong,et al. Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives[J]. MOLECULES,2021,26(11):3249.
APA	Luo,Han,Lv,Yong-Feng,Zhang,Hong,Hu,Jiang-Miao,Li,Hong-Mei,&Liu,Shou-Jin.(2021).Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives.MOLECULES,26(11),3249.
MLA	Luo,Han,et al."Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives".MOLECULES 26.11(2021):3249.