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| Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae | |
| Gao,Rong-Rong; Liu,Zhi-Fang; Yang,Xue-Fei; Song,Yu-Liang; Cui,Xiao-Yun; Yang,Ji-Yuan; Lu,Chun-Hua; Shen,Yue-Mao | |
| 2021 | |
| Source Publication | PHYTOCHEMISTRY
 |
| ISSN | 0031-9422 |
| Volume | 192Pages:112929 |
| Abstract | From the aerial extracts of Coptosapelta diffusa (Champ. ex Benth.) Steenis, twenty-one compounds were isolated and identified by means of column chromatography and NMR and MS techniques, respectively. Amongst, ten ones were determined to be undescribed compounds including six seco-iridoid glucosides (1-6), 2-(hydroxymethyl)-1,2,3,4-tetrahydroanthracene-9,10-dione (7) and three guaiane-type sesquiterpenes (15-17). Compounds 7, 8 and 9 exhibited inhibitory activities against Staphylococcus aureus ATCC25923 with MIC of 8, 4 and 8 mu g/mL. The use of 1-6 (iridoids), 7-14 (anthraquinones) and 15-17 (sesquiterpenes) as chemotaxonomic markers for this species was evidenced. Structurally, 7-14 are similar to those anthraquinones isolated from other species of the family Rubiaceae, confirming their close phylogenetic relationship. Whereas, these iridoids and sesquiterpenes with unique structures provided chemotaxonomic evidence to support the genus Coptosapelta (the tribe Coptosapelteae) as a sister of the subfamily Rubioideae. These results contrast with the general producing tendency of indole alkaloids by the species of the subfamily Cinchonoideae, and merit chemotaxonomic significance for the delimitation of Coptosapelta. |
| Keyword | Coptosapelta diffusa Rubiaceae Phytochemical investigation Seco-iridoid glucosides Guaiane-type sesquiterpenes GUAIANE SESQUITERPENOIDS ABSOLUTE-CONFIGURATION SECONDARY METABOLITES IRIDOID GLYCOSIDES FATTY-ACID FAMILY THYSANOSPERMUM ANTHRAQUINONES CONSTITUENTS ASSIGNMENT |
| DOI | 10.1016/j.phytochem.2021.112929 |
| WOS ID | WOS:000697057100005 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/73441 |
| Collection | 中国科学院昆明植物研究所 |
| Affiliation | 1.[Gao, Rong-Rong 2.Liu, Zhi-Fang 3.Song, Yu-Liang 4.Cui, Xiao-Yun 5.Yang, Ji-Yuan 6.Lu, Chun-Hua 7.Shandong Univ, Sch Pharmaceut Sci, Cheeloo Coll Med, Dept Nat Prod Chem,Key Lab Chem Biol,Minist Educ, Jinan 250012, Peoples R China 8.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Gao,Rong-Rong,Liu,Zhi-Fang,Yang,Xue-Fei,et al. Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae[J]. PHYTOCHEMISTRY,2021,192:112929. |
| APA | Gao,Rong-Rong.,Liu,Zhi-Fang.,Yang,Xue-Fei.,Song,Yu-Liang.,Cui,Xiao-Yun.,...&Shen,Yue-Mao.(2021).Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae.PHYTOCHEMISTRY,192,112929. |
| MLA | Gao,Rong-Rong,et al."Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae".PHYTOCHEMISTRY 192(2021):112929. |
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