Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae

doi:10.1016/j.phytochem.2021.112929

KIB OpenIR

	Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae
	Gao,Rong-Rong ; Liu,Zhi-Fang ; Yang,Xue-Fei ; Song,Yu-Liang ; Cui,Xiao-Yun ; Yang,Ji-Yuan ; Lu,Chun-Hua ; Shen,Yue-Mao
	2021
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	192 页码:112929
摘要	From the aerial extracts of Coptosapelta diffusa (Champ. ex Benth.) Steenis, twenty-one compounds were isolated and identified by means of column chromatography and NMR and MS techniques, respectively. Amongst, ten ones were determined to be undescribed compounds including six seco-iridoid glucosides (1-6), 2-(hydroxymethyl)-1,2,3,4-tetrahydroanthracene-9,10-dione (7) and three guaiane-type sesquiterpenes (15-17). Compounds 7, 8 and 9 exhibited inhibitory activities against Staphylococcus aureus ATCC25923 with MIC of 8, 4 and 8 mu g/mL. The use of 1-6 (iridoids), 7-14 (anthraquinones) and 15-17 (sesquiterpenes) as chemotaxonomic markers for this species was evidenced. Structurally, 7-14 are similar to those anthraquinones isolated from other species of the family Rubiaceae, confirming their close phylogenetic relationship. Whereas, these iridoids and sesquiterpenes with unique structures provided chemotaxonomic evidence to support the genus Coptosapelta (the tribe Coptosapelteae) as a sister of the subfamily Rubioideae. These results contrast with the general producing tendency of indole alkaloids by the species of the subfamily Cinchonoideae, and merit chemotaxonomic significance for the delimitation of Coptosapelta.
关键词	Coptosapelta diffusa Rubiaceae Phytochemical investigation Seco-iridoid glucosides Guaiane-type sesquiterpenes GUAIANE SESQUITERPENOIDS ABSOLUTE-CONFIGURATION SECONDARY METABOLITES IRIDOID GLYCOSIDES FATTY-ACID FAMILY THYSANOSPERMUM ANTHRAQUINONES CONSTITUENTS ASSIGNMENT
DOI	10.1016/j.phytochem.2021.112929
WOS记录号	WOS:000697057100005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73441
专题	中国科学院昆明植物研究所
作者单位	1.[Gao, Rong-Rong 2.Liu, Zhi-Fang 3.Song, Yu-Liang 4.Cui, Xiao-Yun 5.Yang, Ji-Yuan 6.Lu, Chun-Hua 7.Shandong Univ, Sch Pharmaceut Sci, Cheeloo Coll Med, Dept Nat Prod Chem,Key Lab Chem Biol,Minist Educ, Jinan 250012, Peoples R China 8.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Gao,Rong-Rong,Liu,Zhi-Fang,Yang,Xue-Fei,et al. Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae[J]. PHYTOCHEMISTRY,2021,192:112929.
APA	Gao,Rong-Rong.,Liu,Zhi-Fang.,Yang,Xue-Fei.,Song,Yu-Liang.,Cui,Xiao-Yun.,...&Shen,Yue-Mao.(2021).Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae.PHYTOCHEMISTRY,192,112929.
MLA	Gao,Rong-Rong,et al."Specialised metabolites as chemotaxonomic markers of Coptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae".PHYTOCHEMISTRY 192(2021):112929.