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Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents
Su,Hai-Guo; Wang,Qian; Zhou,Lin; Peng,Xing-Rong; Xiong,Wen-Yong; Qiu,Ming -Hua
2021
发表期刊BIOORGANIC CHEMISTRY
ISSN0045-2068
卷号112页码:104977
摘要Previously, we have demonstrated the antiadipogenic benefits of Ganoderma triterpenoids (GTs), which indicated GTs have potential therapeutic implications for obesity. In this study, the EtOAc extract of Ganoderma applanatum was further phytochemically investigated for searching new antiadipogenic agents, which led to the isolation of a total of 15 highly oxygenated lanostane triterpenoids, including 9 new compounds (1-9) and 6 known analogues (10-15). Structurally, ganodapplanoic acids A and B (1, 2) are two rearranged 6/6/5/6-fused lanostane-type triterpenoids with an unusual C-13/C-15 oxygen bridge moiety. In addition, the EtOAc extract (GAE) and isolates (1-4,6-15) were assayed for their antiadipogenic effects in 3T3-L1 adipocytes. The results revealed that compound 9 effectively repressed adipogenesis through down-regulating the expression of major proteins (PPAR gamma, CEBP beta and FAS) involving differentiation and adipogenesis in 3T3-L1 adipocytes. Thus, the present study further demonstrated the antiadipogenic potential of GTs and provided a possible perspective for obesity treatment.
关键词Ganoderma applanatum Lanostane triterpenoids Antiadipogenic effects LANOSTANE-TYPE TRITERPENOIDS ACID
DOI10.1016/j.bioorg.2021.104977
WOS记录号WOS:000661870700007
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73379
专题中国科学院昆明植物研究所
作者单位1.[Su, Hai-Guo
2.Wang, Qian
3.Zhou, Lin
4.Peng, Xing-Rong
5.Xiong, Wen-Yong
6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
8.Yunnan Univ, Key Lab Med Chem Nat Resource, Kunming 650500, Yunnan, Peoples R China
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GB/T 7714
Su,Hai-Guo,Wang,Qian,Zhou,Lin,et al. Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents[J]. BIOORGANIC CHEMISTRY,2021,112:104977.
APA Su,Hai-Guo,Wang,Qian,Zhou,Lin,Peng,Xing-Rong,Xiong,Wen-Yong,&Qiu,Ming -Hua.(2021).Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents.BIOORGANIC CHEMISTRY,112,104977.
MLA Su,Hai-Guo,et al."Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents".BIOORGANIC CHEMISTRY 112(2021):104977.
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