Notoginsenoids, a new class of hexa-nortriterpenoids from biotransformation of Panax notoginseng saponins

doi:10.1016/j.molstruc.2021.132096

KIB OpenIR

	Notoginsenoids, a new class of hexa-nortriterpenoids from biotransformation of Panax notoginseng saponins
	Shang,Jia-Huan ; Li,Yong-Xiang ; Zhu,Hong-Tao ; Wang,Dong; Qiao,Yi-Jun ; Yang,Chong-Ren ; Zhang,Ying-Jun
	2022
Source Publication	JOURNAL OF MOLECULAR STRUCTURE
ISSN	0022-2860
Volume	1252 Pages:132096
Abstract	Notoginsenoids T1-T7, a new class of hexa-nortriterpenoids including two dimers and five monomers, possessing an unprecedented 9-en-5-ketone tricyclic hexa-nordammar skeleton and a variable side chain at C-17, were obtained from biotransformation of PPD-type dammarane saponins by the soil harvested with Panax notoginseng (Araliaceae), a famous traditional Chinese medicinal herb. Their structures were unambiguously determined by spectroscopic, single-crystal X-ray diffraction, Mo-2(AcO)(4)-induced CD and ECD analyzes. A plausible biotransformed pathway for T1-T7 was proposed. Notoginsenoids T1-T5 showed growth inhibitory effects on the probiotic and pathogenic fungi of P. notoginseng. (C) 2021 Elsevier B.V. All rights reserved.
Keyword	Panax notoginseng saponins Hexa-nortriterpenoids Biotransformation Antifungal activity X-ray analysis MICROBIAL TRANSFORMATION ABSOLUTE-CONFIGURATION 20(S)-PROTOPANAXATRIOL DIFFERENTIATION BIOSYNTHESIS MO-2(OAC)(4) METABOLITES
DOI	10.1016/j.molstruc.2021.132096
WOS ID	WOS:000744754700007
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73352
Collection	中国科学院昆明植物研究所
Affiliation	1.[Shang, Jia-Huan 2.Li, Yong-Xiang 3.Zhu, Hong-Tao 4.Wang, Dong 5.Qiao, Yi-Jun 6.Yang, Chong-Ren 7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 9.[Zhu, Hong-Tao 10.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Shang,Jia-Huan,Li,Yong-Xiang,Zhu,Hong-Tao,et al. Notoginsenoids, a new class of hexa-nortriterpenoids from biotransformation of Panax notoginseng saponins[J]. JOURNAL OF MOLECULAR STRUCTURE,2022,1252:132096.
APA	Shang,Jia-Huan.,Li,Yong-Xiang.,Zhu,Hong-Tao.,Wang,Dong.,Qiao,Yi-Jun.,...&Zhang,Ying-Jun.(2022).Notoginsenoids, a new class of hexa-nortriterpenoids from biotransformation of Panax notoginseng saponins.JOURNAL OF MOLECULAR STRUCTURE,1252,132096.
MLA	Shang,Jia-Huan,et al."Notoginsenoids, a new class of hexa-nortriterpenoids from biotransformation of Panax notoginseng saponins".JOURNAL OF MOLECULAR STRUCTURE 1252(2022):132096.

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