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Total Synthesis of Dysifragilones A and B and Dysidavarone C
Li,Yang-Ming; Sun,Yu-Tong; Li,Bi-Yuan; Qin,Hong-Bo
2021
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume23Issue:18Pages:7254-7258
AbstractThe concise synthesis of dysifragilones A and B and dysidavarones has been accomplished for the first time in a divergent way from a common intermediate. The synthetic route features an intramolecular reductive Heck reaction to construct the 6/5/6/6/-tetracycle of dysifragilones A and B and an intramolecular palladium-catalyzed alpha-arylation of a sterically hindered ketone to forge the tetracyclo[7.7.1.0(2,7).0(10,15)]heptadecane core structure of dysidavarone C. The late-stage introduction of amino and ethoxy groups is effective.
KeywordNO PRODUCTION SESQUITERPENE ANALOGS ROUTE
DOI10.1021/acs.orglett.1c02641
WOS IDWOS:000697348600048
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73351
Collection中国科学院昆明植物研究所
Affiliation1.[Li, Yang-Ming
2.Sun, Yu-Tong
3.Li, Bi-Yuan
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
5.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Yunnan Minzu Univ, Sch Chem & Environm, Kunming 650031, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li,Yang-Ming,Sun,Yu-Tong,Li,Bi-Yuan,et al. Total Synthesis of Dysifragilones A and B and Dysidavarone C[J]. ORGANIC LETTERS,2021,23(18):7254-7258.
APA Li,Yang-Ming,Sun,Yu-Tong,Li,Bi-Yuan,&Qin,Hong-Bo.(2021).Total Synthesis of Dysifragilones A and B and Dysidavarone C.ORGANIC LETTERS,23(18),7254-7258.
MLA Li,Yang-Ming,et al."Total Synthesis of Dysifragilones A and B and Dysidavarone C".ORGANIC LETTERS 23.18(2021):7254-7258.
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