Total Synthesis of Dysifragilones A and B and Dysidavarone C

doi:10.1021/acs.orglett.1c02641

KIB OpenIR

	Total Synthesis of Dysifragilones A and B and Dysidavarone C
	Li,Yang-Ming ; Sun,Yu-Tong ; Li,Bi-Yuan ; Qin,Hong-Bo
	2021
Source Publication	ORGANIC LETTERS
ISSN	1523-7060
Volume	23 Issue:18 Pages:7254-7258
Abstract	The concise synthesis of dysifragilones A and B and dysidavarones has been accomplished for the first time in a divergent way from a common intermediate. The synthetic route features an intramolecular reductive Heck reaction to construct the 6/5/6/6/-tetracycle of dysifragilones A and B and an intramolecular palladium-catalyzed alpha-arylation of a sterically hindered ketone to forge the tetracyclo[7.7.1.0(2,7).0(10,15)]heptadecane core structure of dysidavarone C. The late-stage introduction of amino and ethoxy groups is effective.
Keyword	NO PRODUCTION SESQUITERPENE ANALOGS ROUTE
DOI	10.1021/acs.orglett.1c02641
WOS ID	WOS:000697348600048
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73351
Collection	中国科学院昆明植物研究所
Affiliation	1.[Li, Yang-Ming 2.Sun, Yu-Tong 3.Li, Bi-Yuan 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Yunnan Minzu Univ, Sch Chem & Environm, Kunming 650031, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Li,Yang-Ming,Sun,Yu-Tong,Li,Bi-Yuan,et al. Total Synthesis of Dysifragilones A and B and Dysidavarone C[J]. ORGANIC LETTERS,2021,23(18):7254-7258.
APA	Li,Yang-Ming,Sun,Yu-Tong,Li,Bi-Yuan,&Qin,Hong-Bo.(2021).Total Synthesis of Dysifragilones A and B and Dysidavarone C.ORGANIC LETTERS,23(18),7254-7258.
MLA	Li,Yang-Ming,et al."Total Synthesis of Dysifragilones A and B and Dysidavarone C".ORGANIC LETTERS 23.18(2021):7254-7258.

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