A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity

doi:10.1016/j.carbpol.2020.117513

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	A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity
	Li,Xiaomei ; Li,Shanni ; Liu,Jie; Lin,Lisha ; Sun,Huifang ; Yang,Wenjiao ; Cai,Ying ; Gao,Na ; Zhou,Lutan ; Qin,Hongbo; Yin,Ronghua ; Zhao,Jinhua
	2021
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	256 页码:117513
摘要	Marine sulfated polysaccharides have aroused widespread concern for their various structures and bioactivities. Peroxide depolymerization is a common strategy in analysis of structures and structure-activity relationships of polysaccharides. However, confirming the depolymerization process and exact structures of the degradation products is still a considerable challenge. This study reported the structures of a fucan sulfate (FS) from sea cucumber Stichopus herrmanni and its depolymerized products (dFS) prepared by peroxide degradation. The FS was elucidated with a highly regular structure, {-3)-L-Fuc(2S)-(alpha 1-}n. Structure analysis of oligosaccharides purified from dFS suggested that peroxide degradation involved in cleavage of glycosidic bonds and oxidative modification of reducing end of sugar residue, while no break in sugar ring was observed. Both FS and series of dFSs exhibited significant anticoagulant activities due to their anti-thrombin effects in presence of heparin cofactor II and their potencies were related to their molecular sizes, dFS with similar to 20 kDa showed the strongest activity.
关键词	fucan sulfate peroxide depolymerization oligosaccharides anti-thrombin activity FUCOSYLATED CHONDROITIN SULFATE FREE-RADICAL DEPOLYMERIZATION PHYSICOCHEMICAL CHARACTERISTICS REPEATING UNIT BODY-WALL SEA FUCOIDAN GLYCOSAMINOGLYCAN POLYSACCHARIDES HEPARIN
DOI	10.1016/j.carbpol.2020.117513
WOS记录号	WOS:000613255400002
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73349
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.South Cent Univ National, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China 3.Chuxiong Med Coll, Chuxiong 675005, Peoples R China 4.Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li,Xiaomei,Li,Shanni,Liu,Jie,et al. A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity[J]. CARBOHYDRATE POLYMERS,2021,256:117513.
APA	Li,Xiaomei.,Li,Shanni.,Liu,Jie.,Lin,Lisha.,Sun,Huifang.,...&Zhao,Jinhua.(2021).A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity.CARBOHYDRATE POLYMERS,256,117513.
MLA	Li,Xiaomei,et al."A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity".CARBOHYDRATE POLYMERS 256(2021):117513.

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