Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii

doi:10.1016/j.bioorg.2021.104834

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	Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii
	Liu,Jun-Hong ; Zhang,Ran-Ran ; Peng,Xing-Rong ; Ding,Zhong-Tao ; Qiu,Ming-Hua
	2021
Source Publication	BIOORGANIC CHEMISTRY
ISSN	0045-2068
Volume	112 Pages:104834
Abstract	Nine new pyrrole alkaloids, including two undescribed dimeric pyrrole 2-carbaldehyde alkaloids, lepipyrrolins A-B (1-2), seven pyrrole-alkaloid derivatives, macapyrrolins D-J (3-9), along with three known ones (10-12) were isolated from the rhizomes of Lepidium meyenii. Their structures and absolute configurations were demonstrated by extensive spectroscopic data (1D, 2D NMR, HRESIMS), and calculated electronic circular dichroism (ECD) experiment. Compounds 1, 3-12 were tested for their nitric oxide inhibitory effects. Furthermore, compound 1 was evaluated for its cytotoxic activity against five human tumor cell lines (HL-60, SMMC-7221, A549, MCF-7, and SW480) in vitro, and displayed selective cytotoxicity against SMMC-7721 with IC50 value of 16.78 +/- 0.49 mu M.
Keyword	Lepidium meyenii Pyrrole 2-carbaldehyde alkaloids Dimers Cytotoxicity THIOHYDANTOIN DERIVATIVES STRUCTURAL ELUCIDATION MACA MACAMIDES WALP. PLANT CROP
DOI	10.1016/j.bioorg.2021.104834
WOS ID	WOS:000661873800009
Citation statistics	Cited Times:5[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73343
Collection	中国科学院昆明植物研究所
Affiliation	1.[Liu, Jun-Hong 2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 3.Zhang, Ran-Ran 4.Peng, Xing-Rong 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Liu,Jun-Hong,Zhang,Ran-Ran,Peng,Xing-Rong,et al. Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii[J]. BIOORGANIC CHEMISTRY,2021,112:104834.
APA	Liu,Jun-Hong,Zhang,Ran-Ran,Peng,Xing-Rong,Ding,Zhong-Tao,&Qiu,Ming-Hua.(2021).Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii.BIOORGANIC CHEMISTRY,112,104834.
MLA	Liu,Jun-Hong,et al."Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii".BIOORGANIC CHEMISTRY 112(2021):104834.

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