Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii

doi:10.1016/j.bioorg.2021.104834

KIB OpenIR

	Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii
	Liu,Jun-Hong ; Zhang,Ran-Ran ; Peng,Xing-Rong ; Ding,Zhong-Tao ; Qiu,Ming-Hua
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	112 页码:104834
摘要	Nine new pyrrole alkaloids, including two undescribed dimeric pyrrole 2-carbaldehyde alkaloids, lepipyrrolins A-B (1-2), seven pyrrole-alkaloid derivatives, macapyrrolins D-J (3-9), along with three known ones (10-12) were isolated from the rhizomes of Lepidium meyenii. Their structures and absolute configurations were demonstrated by extensive spectroscopic data (1D, 2D NMR, HRESIMS), and calculated electronic circular dichroism (ECD) experiment. Compounds 1, 3-12 were tested for their nitric oxide inhibitory effects. Furthermore, compound 1 was evaluated for its cytotoxic activity against five human tumor cell lines (HL-60, SMMC-7221, A549, MCF-7, and SW480) in vitro, and displayed selective cytotoxicity against SMMC-7721 with IC50 value of 16.78 +/- 0.49 mu M.
关键词	Lepidium meyenii Pyrrole 2-carbaldehyde alkaloids Dimers Cytotoxicity THIOHYDANTOIN DERIVATIVES STRUCTURAL ELUCIDATION MACA MACAMIDES WALP. PLANT CROP
DOI	10.1016/j.bioorg.2021.104834
WOS记录号	WOS:000661873800009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73343
专题	中国科学院昆明植物研究所
作者单位	1.[Liu, Jun-Hong 2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 3.Zhang, Ran-Ran 4.Peng, Xing-Rong 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu,Jun-Hong,Zhang,Ran-Ran,Peng,Xing-Rong,et al. Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii[J]. BIOORGANIC CHEMISTRY,2021,112:104834.
APA	Liu,Jun-Hong,Zhang,Ran-Ran,Peng,Xing-Rong,Ding,Zhong-Tao,&Qiu,Ming-Hua.(2021).Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii.BIOORGANIC CHEMISTRY,112,104834.
MLA	Liu,Jun-Hong,et al."Lepipyrrolins A-B, two new dimeric pyrrole 2-carbaldehyde alkaloids from the tubers of Lepidium meyenii".BIOORGANIC CHEMISTRY 112(2021):104834.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
060-E08-165.pdf（1035KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载