Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)

doi:10.3390/molecules26164934

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	Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)
	Zhang,Ranran ; Liu,Junhong ; Yan,Hui ; Peng,Xingrong ; Zhang,Ling ; Qiu,Minghua
	2021
发表期刊	MOLECULES
ISSN	1420-3049
卷号	26 期号:16 页码:4934
摘要	Five new thiohydantoin derivatives (1-5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound 1 was the first example of thiohydantoins with thioxohexahydroimidazo [1,5-a] pyridine moiety. Additionally, compounds 2 and 3 possess rare disulfide bonds. Except for compound 4, all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (-)-3 exhibited moderate neuroprotective activity (cell viability: 68.63%, 20 mu M) compared to the positive control desipramine (DIM) (cell viability: 88.49%, 10 mu M).
关键词	Lepidium meyenii thiohydantoins thioxohexahydroimidazo [1 5-a] pyridine neuroprotective activities IMIDAZOLE ALKALOIDS DERIVATIVES EXTRACTION MACAMIDES HYDANTOIN ANALOGS TUBERS
DOI	10.3390/molecules26164934
WOS记录号	WOS:000690030400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73342
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang,Ranran,Liu,Junhong,Yan,Hui,et al. Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)[J]. MOLECULES,2021,26(16):4934.
APA	Zhang,Ranran,Liu,Junhong,Yan,Hui,Peng,Xingrong,Zhang,Ling,&Qiu,Minghua.(2021).Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.).MOLECULES,26(16),4934.
MLA	Zhang,Ranran,et al."Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)".MOLECULES 26.16(2021):4934.

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