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Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)
Zhang,Ranran; Liu,Junhong; Yan,Hui; Peng,Xingrong; Zhang,Ling; Qiu,Minghua
2021
Source PublicationMOLECULES
ISSN1420-3049
Volume26Issue:16Pages:4934
AbstractFive new thiohydantoin derivatives (1-5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound 1 was the first example of thiohydantoins with thioxohexahydroimidazo [1,5-a] pyridine moiety. Additionally, compounds 2 and 3 possess rare disulfide bonds. Except for compound 4, all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (-)-3 exhibited moderate neuroprotective activity (cell viability: 68.63%, 20 mu M) compared to the positive control desipramine (DIM) (cell viability: 88.49%, 10 mu M).
KeywordLepidium meyenii thiohydantoins thioxohexahydroimidazo [1 5-a] pyridine neuroprotective activities IMIDAZOLE ALKALOIDS DERIVATIVES EXTRACTION MACAMIDES HYDANTOIN ANALOGS TUBERS
DOI10.3390/molecules26164934
WOS IDWOS:000690030400001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73342
Collection中国科学院昆明植物研究所
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang,Ranran,Liu,Junhong,Yan,Hui,et al. Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)[J]. MOLECULES,2021,26(16):4934.
APA Zhang,Ranran,Liu,Junhong,Yan,Hui,Peng,Xingrong,Zhang,Ling,&Qiu,Minghua.(2021).Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.).MOLECULES,26(16),4934.
MLA Zhang,Ranran,et al."Macathiohydantoin L, a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.)".MOLECULES 26.16(2021):4934.
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