Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.)

doi:10.1002/cjoc.202100353

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	Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.)
	Peng,Xing-Rong ; Zhang,Ran-Ran ; Liu,Jun-Hong ; Li,Zhong-Rong ; Zhou,Lin ; Qiu,Ming-Hua
	2021
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
卷号	39 期号:10 页码:2738-2744
摘要	Main observation and conclusionAn HPLC-UV-guided separation was performed and four pairs of unprecedented macathiohydantoin dimers, lepithiohydimerins A-D (1-4) bearing a rare disulfide bond were isolated from the tubers of Maca. Their structures were unambiguously confirmed by NMR spectroscopic, X-ray crystallographic and electronic circular dichroism (ECD) analyses. At the concentration of 20 mu mol/L, compounds 2-1, 2-2, and 4-1 increased the viability of PC12 cells with the cell viability at (72.06 +/- 1.14)%, (72.64 +/- 1.49)%, and (70.93 +/- 1.22)%, respectively. Furthermore, the serial concentration experiment showed that they can protect PC12 cells in a dose-dependent manner.
关键词	Lepidium meyenii Walp Thiohydantoin dimers Natural products Structure elucidation Biological activity STRUCTURAL ELUCIDATION DERIVATIVES ANTIOXIDANT HYDANTOIN
DOI	10.1002/cjoc.202100353
WOS记录号	WOS:000681331200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73333
专题	中国科学院昆明植物研究所
作者单位	1.[Peng, Xing-Rong 2.Zhang, Ran-Ran 3.Liu, Jun-Hong 4.Li, Zhong-Rong 5.Zhou, Lin 6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 7.[Zhang, Ran-Ran 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Peng,Xing-Rong,Zhang,Ran-Ran,Liu,Jun-Hong,et al. Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.)[J]. CHINESE JOURNAL OF CHEMISTRY,2021,39(10):2738-2744.
APA	Peng,Xing-Rong,Zhang,Ran-Ran,Liu,Jun-Hong,Li,Zhong-Rong,Zhou,Lin,&Qiu,Ming-Hua.(2021).Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.).CHINESE JOURNAL OF CHEMISTRY,39(10),2738-2744.
MLA	Peng,Xing-Rong,et al."Lepithiohydimerins A-D: Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca (Lepidium meyenii Walp.)".CHINESE JOURNAL OF CHEMISTRY 39.10(2021):2738-2744.

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