The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly

doi:10.1093/molbev/msaa199

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	The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly
	Wang,Xin-Jia ; Barrett,Spencer C. H.; Zhong,Li ; Wu,Zhi-Kun ; Li,De-Zhu; Wang,Hong; Zhou,Wei
	2021
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	38 期号:1 页码:168-180
摘要	The evolutionary transition from outcrossing to selfing can have important genomic consequences. Decreased effective population size and the reduced efficacy of selection are predicted to play an important role in the molecular evolution of the genomes of selfing species. We investigated evidence for molecular signatures of the genomic selfing syndrome using 66 species of Primula including distylous (outcrossing) and derived homostylous (selfing) taxa. We complemented our comparative analysis with a microevolutionary study of P. chungensis, which is polymorphic for mating system and consists of both distylous and homostylous populations. We generated chloroplast and nuclear genomic data sets for distylous, homostylous, and distylous-homostylous species and identified patterns of nonsynonymous to synonymous divergence (d(N)/d(S)) and polymorphism (pi(N)/pi(S)) in species or lineages with contrasting mating systems. Our analysis of coding sequence divergence and polymorphism detected strongly reduced genetic diversity and heterozygosity, decreased efficacy of purifying selection, purging of large-effect deleterious mutations, and lower rates of adaptive evolution in samples from homostylous compared with distylous populations, consistent with theoretical expectations of the genomic selfing syndrome. Our results demonstrate that self-fertilization is a major driver of molecular evolutionary processes with genomic signatures of selfing evident in both old and relatively young homostylous populations.
关键词	deleterious mutations effective population size mating system Primula selection efficacy ADAPTIVE MOLECULAR EVOLUTION MATING SYSTEM BREEDING SYSTEMS DELETERIOUS MUTATIONS PURIFYING SELECTION POPULATION-SIZE LINKAGE DISEQUILIBRIUM INBREEDING DEPRESSION PHYLOGENETIC ANALYSES BACKGROUND SELECTION
DOI	10.1093/molbev/msaa199
WOS记录号	WOS:000609977100014
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73258
专题	中国科学院昆明植物研究所
作者单位	1.[Wang, Xin-Jia 2.Zhong, Li 3.Li, De-Zhu 4.Wang, Hong 5.Chinese Acad Sci, Kunming Inst Bot, CAS Key Lab Plant Divers & Biogeog East Asia, Kunming, Yunnan, Peoples R China 6.Chinese Acad Sci, Plant Germplasm & Genom Ctr, Kunming Inst Bot, Germplasm Bank Wild Species, Kunming, Yunnan, Peoples R China 7.Univ Chinese Acad Sci, Beijing, Peoples R China 8.[Barrett, Spencer C. H.] Univ Toronto, Dept Ecol & Evolutionary Biol, Toronto, ON, Canada 9.Guizhou Univ Tradit Chinese Med, Dept Pharm, Guiyang, Guizhou, Peoples R China
推荐引用方式 GB/T 7714	Wang,Xin-Jia,Barrett,Spencer C. H.,Zhong,Li,et al. The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(1):168-180.
APA	Wang,Xin-Jia.,Barrett,Spencer C. H..,Zhong,Li.,Wu,Zhi-Kun.,Li,De-Zhu.,...&Zhou,Wei.(2021).The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly.MOLECULAR BIOLOGY AND EVOLUTION,38(1),168-180.
MLA	Wang,Xin-Jia,et al."The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly".MOLECULAR BIOLOGY AND EVOLUTION 38.1(2021):168-180.

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