Traditional uses, chemical constituents, pharmacological activities, and toxicological effects of Dendrobium leaves: A review

doi:10.1016/j.jep.2021.113851

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	Traditional uses, chemical constituents, pharmacological activities, and toxicological effects of Dendrobium leaves: A review
	Wang,Yue-Hu
	2021
发表期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
卷号	270 页码:113851
摘要	Ethnopharmacological relevance: In China, shi hu (stems of Dendrobium chrysotoxum Lindl, D. fimbriatum Hook. D. huoshanense Z.Z. Tang & S.J. Cheng, or D. nobile Lindl) and tie pi shi hu (stems of D. officinale Kimura et Migo) are famous traditional medicines and are listed in the Chinese Pharmacopoeia. However, the leaves of these Dendrobium plants are largely discarded.Aim of the study: To better utilize Dendrobium leaves, we summarize their traditional uses, chemical constituents, pharmacological activities, and toxicological effects.Materials and methods: Orchidaceae, Dendrobium, leaf', traditional use, and ethnobotany were used as search terms to screen the literature. Cited references were collected between 1960 and 2020 from the Web of Science, China National Knowledge Internet (CNKI), SciFinder, and Google Scholar, primarily in English and Chinese.Results: Traditional uses of leaves from 16 Dendrobium species were identified in the literature. The major uses of Dendrobium leaves include treatments for dermatologic disorders, metabolic syndromes, nervous system disorders, and musculoskeletal system disorders. More than 50 chemical compounds have been identified in the leaves of 10 Dendrobium species, which primarily include flavonoids, bibenzyls, coumarins, N-containing compounds, and polysaccharides. Antihyperlipidemia, antihypertensive, antihyperuricemia, anti-inflammatory, antimicrobial, antioxidant, cytotoxic and antitumor, hepatopmtective, immunomodulatory, lipase-inhibitory, and/or tyrosinase-inhibitory activities have been reported for the leaves of six Dendrobium species. D. officinale leaves have been shown to exhibit no reproductive toxicity against male rats, while D. speciosum Sm. leaves have been observed to exhibit slight genotoxicity in an in vitro study. Among Dendrobium species, D. officinale leaves are the most widely studied.Conclusions: D. officinale leaves represent a good example of the utilization of leaf resources of the Dendrobium genus. In the future, more extensive research for the development of Dendrobium leaves is needed.
关键词	Orchidaceae Dendrobium leaves Flavonoids Polysaccharides Antioxidant activities
DOI	10.1016/j.jep.2021.113851
WOS记录号	WOS:000618539700001
引用统计	被引频次：63[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73237
专题	中国科学院昆明植物研究所
作者单位	Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Yunnan Key Lab Wild Plant Resources & Bioinnovat, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang,Yue-Hu. Traditional uses, chemical constituents, pharmacological activities, and toxicological effects of Dendrobium leaves: A review[J]. JOURNAL OF ETHNOPHARMACOLOGY,2021,270:113851.
APA	Wang,Yue-Hu.(2021).Traditional uses, chemical constituents, pharmacological activities, and toxicological effects of Dendrobium leaves: A review.JOURNAL OF ETHNOPHARMACOLOGY,270,113851.
MLA	Wang,Yue-Hu."Traditional uses, chemical constituents, pharmacological activities, and toxicological effects of Dendrobium leaves: A review".JOURNAL OF ETHNOPHARMACOLOGY 270(2021):113851.