Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium

doi:10.1080/03601234.2021.2022945

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	Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium
	Lan,Mingxian ; Gao,Xi ; Duan,Xiuan ; Li,Hongmei ; Yu,Hang ; Li,Jinliang ; Zhao,Yueqin ; Hao,Xiaojiang; Zhao,Yuhan ; Ding,Xiao ; Wu,Guoxing
	2021
发表期刊	JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
ISSN	0360-1234
摘要	Acetylcholinesterase (AChE) is an enzyme that catalyzes acetylcholine into choline and acetic acid. Conventional pesticides, including organophosphates and carbamates target and inhibit the activity of AChE. To obtain more pesticide precursors that meet the safety requirements, more than 200 compounds were screened. Tirotundin and parthenolide identified as potential neurotoxins to nematodes were isolated from Tithonia diversifolia and Chrysanthemum parthenium, respectively. Their IC50 values were 6.89 +/- 0.30 and 5.51 +/- 0.23 mu g/mL, respectively against the AChE isolated from Caenorhabditis elegans. AChE was inhibited in a dose-dependent manner using the two compounds. And the Lineweaver-Burk and Dixon plots indicated that tirotundin and parthenolide were reversible inhibitors against AChE, both inhibiting AChE in a mixed-type competitive manner and demonstrating these compounds may possess dual binding site AChE inhibitors. LC50 values of tirotundin and parthenolide against C. elegans were 9.16 +/- 0.21 and 7.23 +/- 0.48 mu g/mL, respectively. These results provide a certain theoretical basis for the development and utilization of novel pesticides.
关键词	Parthenolide tirotundin acetylcholinesterase enzyme kinetics toxic effects SESQUITERPENE LACTONE ANTICANCER FLAVONOIDS EXTRACT ANALOG
DOI	10.1080/03601234.2021.2022945
WOS记录号	WOS:000739127300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73213
专题	中国科学院昆明植物研究所
作者单位	1.Yunnan Agr Univ, State Key Lab Conservat & Utilizat Bioresources Y, Kunming 650100, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Green Dev Ctr Baoshan City, Agroenvironm Monitoring Ctr Baoshan City, Baoshan, Peoples R China
推荐引用方式 GB/T 7714	Lan,Mingxian,Gao,Xi,Duan,Xiuan,et al. Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium[J]. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES,2021.
APA	Lan,Mingxian.,Gao,Xi.,Duan,Xiuan.,Li,Hongmei.,Yu,Hang.,...&Wu,Guoxing.(2021).Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium.JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES.
MLA	Lan,Mingxian,et al."Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium".JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES (2021).

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