Oxidative Stress in Dairy Cows: Insights into the Mechanistic Mode of Actions and Mitigating Strategies

doi:10.3390/antiox10121918

KIB OpenIR

	Oxidative Stress in Dairy Cows: Insights into the Mechanistic Mode of Actions and Mitigating Strategies
	Ayemele,Aurele Gnetegha ; Tilahun,Mekonnen ; Sun,Lingling ; Elsaadawy,Samy Abdelaziz ; Guo,Zitai ; Zhao,Gaojuan ; Xu,Jianchu; Bu,Dengpan
	2021
发表期刊	ANTIOXIDANTS
ISSN	2076-3921
卷号	10 期号:12 页码:1918
摘要	This review examines several molecular mechanisms underpinning oxidative stress in ruminants and their effects on blood and milk oxidative traits. We also investigate strategies to alleviate or repair oxidative damages by improving animal immune functions using novel feed additives. Microbial pathogenic cells, feeding management, and body condition score were some of the studied factors, inducing oxidative stress in ruminants. The predominance of Streptococcus spp. (24.22%), Acinetobacter spp. (21.37%), Romboutsia spp. (4.99%), Turicibacter spp., (2.64%), Stenotrophomonas spp. (2.33%), and Enterococcus spp. (1.86%) was found in the microbiome of mastitis cows with a decrease of d-mannose and increase of xanthine:guanine ratio when Streptococcus increased. Diversity of energy sources favoring the growth of Fusobacterium make it a keystone taxon contributing to metritis. Ruminal volatile fatty acids rose with high-concentrate diets that decreased the ruminal pH, causing a lysis of rumen microbes and release of endotoxins. Moreover, lipopolysaccharide (LPS) concentration, malondialdehyde (MDA), and superoxide dismutase (SOD) activities increased in high concentrate cows accompanied by a reduction of total antioxidant capacity (T-AOC), glutathione peroxidase (GPx), and catalase (CAT) activity. In addition, albumin and paraoxonase concentrations were inversely related to oxidative stress and contributed to the protection of low-density and high-density lipoproteins against lipid peroxidation, protein carbonyl, and lactoperoxidase. High concentrate diets increased the expression of MAPK pro-inflammatory genes and decreased the expression of antioxidant genes and proteins in mammary epithelial tissues. The expression levels of NrF2, NQO1, MT1E, UGT1A1, MGST3, and MT1A were downregulated, whereas NF-kB was upregulated with a high-grain or high concentrate diet. Amino-acids, vitamins, trace elements, and plant extracts have shown promising results through enhancing immune functions and repairing damaged cells exposed to oxidative stress. Further studies comparing the long-term effect of synthetic feed additives and natural plant additives on animal health and physiology remain to be investigated.
关键词	antioxidants genes feed additives immune function pathogenic microbial cells pro-inflammatory genes SUBACUTE RUMINAL ACIDOSIS BODY CONDITION SCORE RUMEN-PROTECTED METHIONINE SOMATIC-CELL COUNT MILK-PRODUCTION AMINO-ACIDS IMMUNE FUNCTION ANTIOXIDANT STATUS TRANSITION PERIOD DIGESTIVE-TRACT
DOI	10.3390/antiox10121918
WOS记录号	WOS:000735832600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73180
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Honghe Ctr Mt Futures, Beijing 654400, Honghe County, Peoples R China 3.East & Cent Asia, Agroforestry Ctr, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Agr Sci CAAS, Ethiopian Inst Agr Res EIAR & World Agroforestry, Joint Lab Integrated Crop Tree Livestock Syst, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Ayemele,Aurele Gnetegha,Tilahun,Mekonnen,Sun,Lingling,et al. Oxidative Stress in Dairy Cows: Insights into the Mechanistic Mode of Actions and Mitigating Strategies[J]. ANTIOXIDANTS,2021,10(12):1918.
APA	Ayemele,Aurele Gnetegha.,Tilahun,Mekonnen.,Sun,Lingling.,Elsaadawy,Samy Abdelaziz.,Guo,Zitai.,...&Bu,Dengpan.(2021).Oxidative Stress in Dairy Cows: Insights into the Mechanistic Mode of Actions and Mitigating Strategies.ANTIOXIDANTS,10(12),1918.
MLA	Ayemele,Aurele Gnetegha,et al."Oxidative Stress in Dairy Cows: Insights into the Mechanistic Mode of Actions and Mitigating Strategies".ANTIOXIDANTS 10.12(2021):1918.