Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides

doi:10.1016/j.fitote.2021.105001

KIB OpenIR

	Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides
	Cao,Dong-Hua ; Yao,Jian-Neng ; Sun,Peng ; Ji,Kai-Long ; Li,Xiao-Nian ; Cai,Qiang ; Xiao,Chun-Fen ; Hu,Hua-Bin ; Yu,Zhi-Yong ; Xu,You-Kai
	2021
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	153 页码:105001
摘要	Four new limonoids, named as trichiconlide G (1), 2-hydroxyltrijugin F (2), 23-oxo-21-hydroxyltrijugin F (3), 21-oxo-23-hydroxyltrijugin F (4), along with sixteen known analogues (5-20) were isolated from the leaves and twigs of Trichilia connaroides. Their structures and absolute configurations were determined by spectroscopic analyses, X-ray diffraction analysis, and TD-DFT-ECD calculations. Trichiconlide G (1) is one rare naturally occurring 1,2-seco phragmalin-type limonoid bearing a C-7/28 delta-lactone ring. Additionally, 2-hydroxyltrijugin F (2), 23-oxo-21-hydroxyltrijugin F (3), and 21-oxo-23-hydroxyltrijugin F (4) are three naturally occurring limonoids with a rare C-16/8 delta-lactone ring. All isolates were evaluated for their cytotoxic and anti-inflammatory activities. None of compounds exhibited cytotoxicity against five human cancer cell lines A-549, HepG2, 5-8F, Siha, and SCC-4 at the concentration of 40 mu M. Compounds 16 and 17 showed moderate anti-inflammatory activity with IC50 values of 28.45 +/- 2.51 and 22.66 +/- 2.01 mu M, respectively.
关键词	Trichilia connaroides Meliaceae Limonoid Cytotoxicity Anti-inflammatory NITRIC-OXIDE PRODUCTION CHEMICAL-CONSTITUENTS CARBON SKELETON RECENT PROGRESS TETRANORTRITERPENOIDS LEAVES SEEDS CHEMISTRY STEROIDS TWIGS
DOI	10.1016/j.fitote.2021.105001
WOS记录号	WOS:000684837300008
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73169
专题	中国科学院昆明植物研究所
作者单位	1.Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Changsha 410004, Peoples R China 2.[Cao, Dong-Hua 3.Sun, Peng 4.Ji, Kai-Long 5.Xiao, Chun-Fen 6.Hu, Hua-Bin 7.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China 8.[Yao, Jian-Neng 9.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 10.[Cai, Qiang 11.Second Peoples Hosp Yunnan Prov, Dept Hepatobiliary Surg, Kunming 650021, Peoples R China
推荐引用方式 GB/T 7714	Cao,Dong-Hua,Yao,Jian-Neng,Sun,Peng,et al. Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides[J]. FITOTERAPIA,2021,153:105001.
APA	Cao,Dong-Hua.,Yao,Jian-Neng.,Sun,Peng.,Ji,Kai-Long.,Li,Xiao-Nian.,...&Xu,You-Kai.(2021).Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides.FITOTERAPIA,153,105001.
MLA	Cao,Dong-Hua,et al."Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides".FITOTERAPIA 153(2021):105001.