Neuroprotective compounds from the resinous heartwood of Aquilaria sinensis

doi:10.1016/j.phytochem.2020.112554

KIB OpenIR

	Neuroprotective compounds from the resinous heartwood of Aquilaria sinensis
	He,Qian ; Hu,Dong-Bao ; Zhang,Lu; Xia,Meng-Yuan ; Yan,Hui ; Li,Xiao-Nian ; Luo,Ji-Feng ; Wang,Yun-Song ; Yang,Jing-Hua ; Wang,Yue-Hu
	2021
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	181 页码:112554
摘要	Six undescribed compounds, including three sesquiterpenoids [(4S,5S,7S,8S,11R)-7-hydroxyguai-1(10)-en-8,12-olide, aquilarisinone, and 2Z,7(13),9E-humulatrien-12-ol-5-one], one diphenylpentanone -(2-hydroxyphenyl)5-phenylpentan-3-one], and two 2-(2-phenylethyl)chromones (6-epiagarotetrol and triepoxyhexahydrochromone A), along with 15 known compounds, were isolated from the resinous heartwood of Aquilaria sinensis (Thymelaeaceae). Their structures were determined by mass (MS) and nuclear magnetic resonance (NMR) spectroscopic data. The absolute configuration of (4S,5S,7S,8S,11R)-7-hydroxyguai-1(10)-en-8,12-olide was confirmed by X-ray diffraction analysis, and the configurations of (4S,7S,8S,10R,11R)-7,10-epoxyguai-1(5)-en-8,12-olide, aquilarisinone, 6-epiagarotetrol, and triepoxyhexahydrochromone A were confirmed by electronic circular dichroism (ECD) calculations. The neuroprotective activities of the compounds were evaluated using models of BACE1 inhibition and PC12 cells with corticosterone- and 1-methyl-4-phenylpyridine ion (MPP +/-)induced damage. At concentrations of 1, 2, and 5 mu M, triepoxyhexahydrochromone A, (+)-(7R,10R)-selina-4,11 (13)- diene-12,15- dial, (-)- (5R, 7R,1 OR)-12,15- dioxo-alpha-selinene, and (+)- (1R,4S,5R)-1 beta-hydroxyeremophila-7 (11),9-dien-8-one exerted significant protective effects (p < 0.01) on PC12 cell injury induced by corticosterone, while triepoxyhexahydrochromone A and (-)-(5R,7R,10R)-12,15-dioxo-a-selinene exerted significant protective effects (p < 0.01) on MPP+-induced PC12 cell injury at concentrations of 1, 2, and 5 mu M. No compounds produced significant inhibitory effects on BACE1, with inhibition rates of less than 20% observed at a concentration of 20 mu M.
关键词	Aquilaria sinensis Thymelaeaceae Sesquiterpenoids 2-(2-Phenylethyl)chromones Neuroprotective
DOI	10.1016/j.phytochem.2020.112554
WOS记录号	WOS:000598977700024
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73160
专题	中国科学院昆明植物研究所
作者单位	1.[He, Qian 2.Wang, Yun-Song 3.Yunnan Univ, Chinese Acad Sci, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ,Sch Pha, Kunming 650091, Yunnan, Peoples R China 4.Zhang, Lu 5.Xia, Meng-Yuan 6.Yan, Hui 7.Li, Xiao-Nian 8.Luo, Ji-Feng 9.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China 10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 11.Yuxi Normal Univ, Sch Chem Biol & Environm, Yuxi 653100, Peoples R China
推荐引用方式 GB/T 7714	He,Qian,Hu,Dong-Bao,Zhang,Lu,et al. Neuroprotective compounds from the resinous heartwood of Aquilaria sinensis[J]. PHYTOCHEMISTRY,2021,181:112554.
APA	He,Qian.,Hu,Dong-Bao.,Zhang,Lu.,Xia,Meng-Yuan.,Yan,Hui.,...&Wang,Yue-Hu.(2021).Neuroprotective compounds from the resinous heartwood of Aquilaria sinensis.PHYTOCHEMISTRY,181,112554.
MLA	He,Qian,et al."Neuroprotective compounds from the resinous heartwood of Aquilaria sinensis".PHYTOCHEMISTRY 181(2021):112554.