Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling

doi:10.1016/j.biopha.2020.111107

KIB OpenIR

	Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling
	Wang,Yajie ; Tan,Jiabin ; Hu,Peng ; Pei,Qiang ; Wen,Yan ; Ma,Wenqing ; Shi,Keqian ; Li,Zengzheng ; Li,Huiyuan ; Cheng,Fengyu ; Gu,Xuezhong ; Yao,Xiangmei ; Man,Yan ; Zhao,Renbin ; Feng,Shuai ; Ding,Xiao ; Yang,Tonghua
	2021
发表期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
卷号	134 页码:111107
摘要	The immune system plays a pivotal role in defending against infection and cancer immunosurveillance during the onset and procession of malignant disease. Cancer patients are frequently immunocompromised and subject to refractory infection and relapse of leukemia, due to the cytotoxic agents and immunosuppressive glucocorticoids in the chemotherapy regimens. Bu Shen Hui Yang Fang (BSHY), a traditional Chinese compound, was widely used in China to enhance the immune system of leukemia patients combined with chemotherapy and effectively lowered their risk of infection, with specific mechanism unknown yet. Thus, we investigated the effects of BSHY on the immune system using immunosuppressive mouse models. By analyzing the immune system of immuno-suppressed BALB/C mice induced by hydrocortisone, we found an increase of CD4(+) and CD8(+) lymphocytes in the spleens of mice after BSHY treatment. Furthermore, we found the enhanced immune system in BSHY treated group was due to increased proliferation and decreased apoptosis of lymphocytes. Cytokine array analysis revealed that interleukin 4 (IL-4) was reduced in the plasma of immunosuppressed mice but returned to a normal level after BSHY treatment. Moreover, we found IL-4 was an adverse prognostic factor in acute myeloid leukemia patients and part of them could be elevated by BSHY. Mechanistically, we found BSHY enhances the proliferation of lymphocytes in a Stat6-dependent manner. In summary, our current study demonstrates that BSHY enhances the proliferation of lymphocytes in the immunosuppressed mice via upregulating IL-4 signaling.
关键词	Bu Shen Hui Yang Fang (BSHY) Immunoenhancement Lymphocytes Proliferation Cytokine IL-4 ACUTE MYELOID-LEUKEMIA IMMUNE-SYSTEM CANCER CELLS IMMUNOSURVEILLANCE EXPRESSION
DOI	10.1016/j.biopha.2020.111107
WOS记录号	WOS:000611822700004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73149
专题	中国科学院昆明植物研究所
作者单位	1.Yunnan Blood Dis Hosp, Peoples Hosp Yunnan Prov 1, Yunnan Blood Dis Clin Med Ctr, Natl Key Clin Specialty Hematol,Dept Hematol, Kunming, Yunnan, Peoples R China 2.Kunming Univ Sci & Technol, Kunming, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang,Yajie,Tan,Jiabin,Hu,Peng,et al. Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling[J]. BIOMEDICINE & PHARMACOTHERAPY,2021,134:111107.
APA	Wang,Yajie.,Tan,Jiabin.,Hu,Peng.,Pei,Qiang.,Wen,Yan.,...&Yang,Tonghua.(2021).Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling.BIOMEDICINE & PHARMACOTHERAPY,134,111107.
MLA	Wang,Yajie,et al."Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling".BIOMEDICINE & PHARMACOTHERAPY 134(2021):111107.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
107-H06-054-丁骁-BP.pd（7551KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载