Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum

doi:10.1016/j.tetlet.2020.152733

KIB OpenIR

	Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum
	Zeng,Yanrong ; Yang,Jue ; Li,Yanan ; Gu,Wei; Huang,Liejun ; Yi,Ping ; Yuan,Chunmao ; Hao,Xiaojiang
	2021
发表期刊	TETRAHEDRON LETTERS
ISSN	0040-4039
卷号	64 页码:152733
摘要	Four highly modified polycyclic polyprenylated acylphloroglucinols (PPAPs) with an unusual 6,5,5-tricyclic system, hypermogins A-D (1-4), together with one known analogue (5), were isolated from the flowers of Hypericum monogynum. From a possible biogenic synthesis pathway analysis, compounds 2 and 3 could be obtained by oxidation of a double bond and hydrolysis for 1 and 5. In addition, compound 3 might undergo a pinacol rearrangement to produce compound 4. The structures of the isolates were determined by comprehensive MS, NMR spectroscopy and electronic circular dichroism (ECD) calculations. All compounds significantly reversed multidrug resistance in MCF-7/ADR cells. (C) 2020 Elsevier Ltd. All rights reserved.
关键词	Hypericum monogynum PPAPs Multidrug resistance reversal activity PHLOROGLUCINOL DERIVATIVES
DOI	10.1016/j.tetlet.2020.152733
WOS记录号	WOS:000610242900008
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73122
专题	中国科学院昆明植物研究所
作者单位	1.Guizhou Med Univ, Sch Basic Med Sci, Guiyang 550025, Peoples R China 2.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China 3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China 4.Chinese Acad Sci, Key Lab Phytochem & Plant Resources West China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zeng,Yanrong,Yang,Jue,Li,Yanan,et al. Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum[J]. TETRAHEDRON LETTERS,2021,64:152733.
APA	Zeng,Yanrong.,Yang,Jue.,Li,Yanan.,Gu,Wei.,Huang,Liejun.,...&Hao,Xiaojiang.(2021).Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum.TETRAHEDRON LETTERS,64,152733.
MLA	Zeng,Yanrong,et al."Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum".TETRAHEDRON LETTERS 64(2021):152733.