Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus

doi:10.1016/j.bioorg.2021.105074

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	Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus
	Zheng,Dan ; Chen,Yuyu ; Wan,Shijie ; Jiang,Jiaming ; Chen,Simin ; Zheng,Changwu ; Zhou,Hua ; Xu,Gang; Zhang,Hong ; Xu,Hongxi
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	114 页码:105074
摘要	alpha-Hemolysin (Hla) is an extracellular protein secreted by methicillin-resistant Staphylococcus aureus (MRSA) strains that plays a critical role in the pathogenesis of pulmonary, intraperitoneal, intramammary, and corneal infections, rendering Hla a potential therapeutic target. In this study, 10 unreported polycyclic polyprenylated acylphloroglucinol (PPAP) derivatives, garciyunnanins C-L (1-10), with diverse skeletons, were isolated from Garcinia yunnanensis Hu. The structures of these new compounds were determined by HRMS, NMR, electronic circular dichroism (ECD) calculations, single-crystal X-ray diffraction, and biomimetic transformation. Garciyunnanins C and D (1 and 2) were found to be potent Hla inhibitors in the anti-virulence efficacy evaluation against MRSA strain.
关键词	Garcinia yunnanensis Hu Polycyclic polyprenylated acylphloroglucinols (PPAPs) Staphylococcus aureus alpha-Hemolysin (Hla) BENZOPHENONE DERIVATIVES OBLONGIFOLIN C GUTTIFERONE-K NEUTRALIZATION CALCICOLA VIRULENCE COMPOUND GENE MRSA
DOI	10.1016/j.bioorg.2021.105074
WOS记录号	WOS:000689498000005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73083
专题	中国科学院昆明植物研究所
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Cardiovasc Dis Integrated Tradit Chinese & W, Shanghai 201203, Peoples R China 3.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Ctr Translat Med, Shanghai 200233, Peoples R China 4.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus, Shanghai 200233, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zheng,Dan,Chen,Yuyu,Wan,Shijie,et al. Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus[J]. BIOORGANIC CHEMISTRY,2021,114:105074.
APA	Zheng,Dan.,Chen,Yuyu.,Wan,Shijie.,Jiang,Jiaming.,Chen,Simin.,...&Xu,Hongxi.(2021).Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus.BIOORGANIC CHEMISTRY,114,105074.
MLA	Zheng,Dan,et al."Polycyclic polyprenylated acylphloroglucinol congeners from Garcinia yunnanensis Hu with inhibitory effect on alpha-hemolysin production in Staphylococcus aureus".BIOORGANIC CHEMISTRY 114(2021):105074.