Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect

doi:10.1016/j.indcrop.2021.114441

KIB OpenIR

	Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect
	Chen,Xinglong ; Luo,Qingyi ; Hu,Weiyan ; Chen,Jijun; Zhang,Rongping
	2022
Source Publication	INDUSTRIAL CROPS AND PRODUCTS
ISSN	0926-6690
Volume	177 Pages:114441
Abstract	The aim of this study was to purify and identify new types of secondary products from Rosmarinus officinalis solid wastes after essential oil been extracted, further study their MS/MS spectrometric fragmentations and evaluate their cytoprotective effects against H2O2-induced oxidative damage in SH-SY5Y cells. Six labdane diterpenoids, five isopimarane diterpenoids and two ferulic acid esters were obtained in which three labdane diterpenoids and four isopimarane diterpenoids were undescribed compounds. The losses of hydroxyl, tigloyl, 2-methy-butanoyl, acetyl and carbonyl groups or side chains were the main elimination modes of the new compounds in MS/MS analyses. Compounds 1, 4, 6, 10 and 12 showed the ability to protect the cells against oxidative injure whose cell viability rates were more than 65% in the concentration of 1 or 25 mu M respectively. These studies broadened the understanding of secondary products of rosemary and promoted the deep developments and utilizations of rosemary after essential oil been extracted.
Keyword	Rosmarinus officinalis Solid wastes Labdane diterpenoids Isopimarane diterpenoids MS/MS fragmentations Neuroprotective effect CARNOSIC ACID ANTIOXIDANT ACTIVITY BIOSYNTHESIS
DOI	10.1016/j.indcrop.2021.114441
WOS ID	WOS:000736973700008
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73068
Collection	中国科学院昆明植物研究所
Affiliation	1.Yunnan Univ Chinese Med, Sch Chinese Mat Med, Kunming 650500, Yunnan, Peoples R China 2.Yunnan Univ Chinese Med, Yunnan Key Lab Southern Med Utilizat, Kunming 650500, Yunnan, Peoples R China 3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Chen,Xinglong,Luo,Qingyi,Hu,Weiyan,et al. Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect[J]. INDUSTRIAL CROPS AND PRODUCTS,2022,177:114441.
APA	Chen,Xinglong,Luo,Qingyi,Hu,Weiyan,Chen,Jijun,&Zhang,Rongping.(2022).Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect.INDUSTRIAL CROPS AND PRODUCTS,177,114441.
MLA	Chen,Xinglong,et al."Labdane and isopimarane diterpenoids from Rosmarinus officinalis solid wastes: MS/MS spectrometric fragmentations and neuroprotective effect".INDUSTRIAL CROPS AND PRODUCTS 177(2022):114441.

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