Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities

doi:10.1016/j.fitote.2020.104793

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	Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities
	Geng,Hui-Chun ; Zhu,Hong-Tao ; Wang,Dong; Yang,Wei-Nong ; Yang,Chong-Ren ; Zhang,Ying-Jun
	2021
Source Publication	FITOTERAPIA
ISSN	0367-326X
Volume	148 Pages:104793
Abstract	Phytochemical investigation on the nonpolar extracts of P. acidus leaves afforded three new cleistanthane diterpenoids, named phyllanacidins A-C (1-3) 5 in addition to three known ones (4-6). Among them, compounds 2 and 3 represent the first examples of 17-nor cleistanthane diterpenoids. Their structures including absolute configurations were elucidated on the basis of extensive spectroscopic data and single crystal X-ray diffraction analysis. All the isolated cleistanthane diterpenoids were evaluated for their cytotoxic activities against five human cancer cell lines. Compounds 4-6 exhibited moderate cytotoxicity with IC50 values ranging from 16.11 to 30.82 mu M.
Keyword	Phyllanthus acidus Cleistanthane diterpenoids Cytotoxicity CASSANE
DOI	10.1016/j.fitote.2020.104793
WOS ID	WOS:000604579800007
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Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73042
Collection	中国科学院昆明植物研究所
Affiliation	1.[Geng, Hui-Chun 2.Zhu, Hong-Tao 3.Wang, Dong 4.Yang, Chong-Ren 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Yunnan Acad Agr Sci, Qual Standardizing & Testing Technol Inst, Kunming 650223, Yunnan, Peoples R China 8.Yunnan Xinxing Greening Engn Co, Kunming 650228, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Geng,Hui-Chun,Zhu,Hong-Tao,Wang,Dong,et al. Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities[J]. FITOTERAPIA,2021,148:104793.
APA	Geng,Hui-Chun,Zhu,Hong-Tao,Wang,Dong,Yang,Wei-Nong,Yang,Chong-Ren,&Zhang,Ying-Jun.(2021).Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities.FITOTERAPIA,148,104793.
MLA	Geng,Hui-Chun,et al."Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities".FITOTERAPIA 148(2021):104793.

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