Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla

doi:10.1021/acs.orglett.1c03641

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	Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla
	Zhou,Hao-Feng ; Li,Wen-Yan ; Peng,Li-Yan ; Li,Xiao-Nian ; Zuo,Zhi-Li ; Zhao,Qin-Shi
	2021
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	23 期号:24 页码:9463-9467
摘要	Rhynchines A-E (1-5), five new indole alkaloids with an unprecedented skeleton, were isolated from Uncaria rhynchophylla. The new skeleton was characterized by an indole moiety and a 2-oxa-8-azatricyclo[6,5,0(1,5), 0(1,8)]tridecane core, forming a unique 6/5/7/5/5 ring system. Their structures were determined by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, infrared spectroscopy, and calculated electronic circular dichroism (ECD) and were confirmed by X-ray crystallography. Interestingly, 1 and 2 showed strong inhibitory activities against the Ca-v 3.1 calcium channel with IC50 values of 6.86 and 10.41 mu M.
关键词	INDOLE ALKALOIDS
DOI	10.1021/acs.orglett.1c03641
WOS记录号	WOS:000744124300024
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73012
专题	中国科学院昆明植物研究所
作者单位	1.[Zhou, Hao-Feng 2.Li, Wen-Yan 3.Peng, Li-Yan 4.Li, Xiao-Nian 5.Zuo, Zhi-Li 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhou,Hao-Feng,Li,Wen-Yan,Peng,Li-Yan,et al. Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla[J]. ORGANIC LETTERS,2021,23(24):9463-9467.
APA	Zhou,Hao-Feng,Li,Wen-Yan,Peng,Li-Yan,Li,Xiao-Nian,Zuo,Zhi-Li,&Zhao,Qin-Shi.(2021).Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla.ORGANIC LETTERS,23(24),9463-9467.
MLA	Zhou,Hao-Feng,et al."Rhynchines A-E: Ca(v)3.1 Calcium Channel Blockers from Uncaria rhynchophylla".ORGANIC LETTERS 23.24(2021):9463-9467.

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