Noncoding RNAs and RNA-binding proteins in diabetic wound healing

doi:10.1016/j.bmcl.2021.128311

KIB OpenIR

	Noncoding RNAs and RNA-binding proteins in diabetic wound healing
	Li,Xue; Li,Ning ; Li,Bingxin ; Feng,Yuan ; Zhou,Di ; Chen,Gang
	2021
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	50 页码:128311
摘要	Poor wound healing is a common complication in diabetic patients. It often leads to intractable infections and lower limb amputations and is associated with cardiovascular morbidity and mortality. NcRNAs, which can regulate gene expression, have emerged as important regulators of various physiological processes. Herein, we summarize the diverse roles of ncRNAs in the key stages of diabetic wound healing, including inflammation, angiogenesis, re-epithelialization, and extracellular matrix remodeling. Meanwhile, the potential use of ncRNAs as novel therapeutic targets for wound healing in diabetic patients is also discussed. In addition, we summarize the role of RNA-binding proteins (RBPs) in the regulation of gene expression and signaling pathways during skin repair, which may provide opportunities for therapeutic intervention for this potentially devastating disease. However, so far, research on the modulated drug based on ncRNAs that lead to significantly altered gene expression in diabetic patients is scarce. We have compiled some drugs that may be able to modulate ncRNAs, which significantly regulate the gene expression in diabetic patients.
关键词	ncRNAs lncRNAs circRNAs RNA-binding protein Modulating drugs Diabetic Wound healing ENDOTHELIAL-CELLS OXIDATIVE STRESS PROLIFERATION APOPTOSIS INFLAMMATION DYSFUNCTION EXPRESSION MIGRATION CANCER INJURY
DOI	10.1016/j.bmcl.2021.128311
WOS记录号	WOS:000701795800010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73005
专题	中国科学院昆明植物研究所
作者单位	1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 3.Guangxi Normal Univ, Lab Chem & Mol Engn Med Resources, Guilin, Peoples R China
推荐引用方式 GB/T 7714	Li,Xue,Li,Ning,Li,Bingxin,et al. Noncoding RNAs and RNA-binding proteins in diabetic wound healing[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2021,50:128311.
APA	Li,Xue,Li,Ning,Li,Bingxin,Feng,Yuan,Zhou,Di,&Chen,Gang.(2021).Noncoding RNAs and RNA-binding proteins in diabetic wound healing.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,50,128311.
MLA	Li,Xue,et al."Noncoding RNAs and RNA-binding proteins in diabetic wound healing".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 50(2021):128311.