Potential inhibitors of microglial activation from the roots of Vernicia montana Lour

doi:10.1016/j.phytochem.2021.113019

KIB OpenIR

	Potential inhibitors of microglial activation from the roots of Vernicia montana Lour
	Wang,Yingjie ; Chen,Gang ; Meng,Qingqi ; Yao,Xiaohu ; Li,Yang ; Cao,Honglin ; Lin,Bin ; Hou,Yue ; Zhou,Di ; Li,Ning
	2022
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	194 页码:113019
摘要	During our continuous investigation of natural, herbal inhibitors of microglial over-activation in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory effects on nitric oxide (NO) production in over-activated microglia. In this study, bioactivity-guided phytochemical research on the active fraction of the roots of V. montana was carried out. As a result, seven undescribed terpenoids and lignans, together with thirty-one known components, were isolated and identified using comprehensive spectral analysis. All the identified compounds were evaluated for their inhibitory effects on NO production in lipopolysaccharidestimulated BV-2 cells. Combined with our previous research on the Vernicia genus, the effective material basis of different plants and medicinal components was analyzed systematically.
关键词	Vernicia montana Lour Euphorbiaceae Terpenoids Lignans Microglia ANTIINFLAMMATORY ACTIVITIES MULTIDRUG-RESISTANCE CONSTITUENTS TERPENOIDS NEOLIGNANS DITERPENES LEAVES OIL
DOI	10.1016/j.phytochem.2021.113019
WOS记录号	WOS:000723417800004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73004
专题	中国科学院昆明植物研究所
作者单位	1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China 2.Northeastern Univ, Coll Life & Hlth Sci, Shenyang 110004, Peoples R China 3.Chinese Acad Sci, South China Bot Garden, Guangzhou 510650, Peoples R China 4.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 6.Guangxi Normal Univ, Sate Key Lab Chem & Mol Engn Med Resources, Nanning, Peoples R China
推荐引用方式 GB/T 7714	Wang,Yingjie,Chen,Gang,Meng,Qingqi,et al. Potential inhibitors of microglial activation from the roots of Vernicia montana Lour[J]. PHYTOCHEMISTRY,2022,194:113019.
APA	Wang,Yingjie.,Chen,Gang.,Meng,Qingqi.,Yao,Xiaohu.,Li,Yang.,...&Li,Ning.(2022).Potential inhibitors of microglial activation from the roots of Vernicia montana Lour.PHYTOCHEMISTRY,194,113019.
MLA	Wang,Yingjie,et al."Potential inhibitors of microglial activation from the roots of Vernicia montana Lour".PHYTOCHEMISTRY 194(2022):113019.