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Potential inhibitors of microglial activation from the roots of Vernicia montana Lour
Wang,Yingjie; Chen,Gang; Meng,Qingqi; Yao,Xiaohu; Li,Yang; Cao,Honglin; Lin,Bin; Hou,Yue; Zhou,Di; Li,Ning
2022
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume194Pages:113019
AbstractDuring our continuous investigation of natural, herbal inhibitors of microglial over-activation in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory effects on nitric oxide (NO) production in over-activated microglia. In this study, bioactivity-guided phytochemical research on the active fraction of the roots of V. montana was carried out. As a result, seven undescribed terpenoids and lignans, together with thirty-one known components, were isolated and identified using comprehensive spectral analysis. All the identified compounds were evaluated for their inhibitory effects on NO production in lipopolysaccharidestimulated BV-2 cells. Combined with our previous research on the Vernicia genus, the effective material basis of different plants and medicinal components was analyzed systematically.
KeywordVernicia montana Lour Euphorbiaceae Terpenoids Lignans Microglia ANTIINFLAMMATORY ACTIVITIES MULTIDRUG-RESISTANCE CONSTITUENTS TERPENOIDS NEOLIGNANS DITERPENES LEAVES OIL
DOI10.1016/j.phytochem.2021.113019
WOS IDWOS:000723417800004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73004
Collection中国科学院昆明植物研究所
Affiliation1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China
2.Northeastern Univ, Coll Life & Hlth Sci, Shenyang 110004, Peoples R China
3.Chinese Acad Sci, South China Bot Garden, Guangzhou 510650, Peoples R China
4.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
6.Guangxi Normal Univ, Sate Key Lab Chem & Mol Engn Med Resources, Nanning, Peoples R China
Recommended Citation
GB/T 7714
Wang,Yingjie,Chen,Gang,Meng,Qingqi,et al. Potential inhibitors of microglial activation from the roots of Vernicia montana Lour[J]. PHYTOCHEMISTRY,2022,194:113019.
APA Wang,Yingjie.,Chen,Gang.,Meng,Qingqi.,Yao,Xiaohu.,Li,Yang.,...&Li,Ning.(2022).Potential inhibitors of microglial activation from the roots of Vernicia montana Lour.PHYTOCHEMISTRY,194,113019.
MLA Wang,Yingjie,et al."Potential inhibitors of microglial activation from the roots of Vernicia montana Lour".PHYTOCHEMISTRY 194(2022):113019.
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