Knowledge Management System of Kunming Institute of Botany,CAS
| Potential inhibitors of microglial activation from the roots of Vernicia montana Lour | |
| Wang,Yingjie; Chen,Gang; Meng,Qingqi; Yao,Xiaohu; Li,Yang; Cao,Honglin; Lin,Bin; Hou,Yue; Zhou,Di; Li,Ning | |
| 2022 | |
| Source Publication | PHYTOCHEMISTRY
 |
| ISSN | 0031-9422 |
| Volume | 194Pages:113019 |
| Abstract | During our continuous investigation of natural, herbal inhibitors of microglial over-activation in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory effects on nitric oxide (NO) production in over-activated microglia. In this study, bioactivity-guided phytochemical research on the active fraction of the roots of V. montana was carried out. As a result, seven undescribed terpenoids and lignans, together with thirty-one known components, were isolated and identified using comprehensive spectral analysis. All the identified compounds were evaluated for their inhibitory effects on NO production in lipopolysaccharidestimulated BV-2 cells. Combined with our previous research on the Vernicia genus, the effective material basis of different plants and medicinal components was analyzed systematically. |
| Keyword | Vernicia montana Lour Euphorbiaceae Terpenoids Lignans Microglia ANTIINFLAMMATORY ACTIVITIES MULTIDRUG-RESISTANCE CONSTITUENTS TERPENOIDS NEOLIGNANS DITERPENES LEAVES OIL |
| DOI | 10.1016/j.phytochem.2021.113019 |
| WOS ID | WOS:000723417800004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/73004 |
| Collection | 中国科学院昆明植物研究所 |
| Affiliation | 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China 2.Northeastern Univ, Coll Life & Hlth Sci, Shenyang 110004, Peoples R China 3.Chinese Acad Sci, South China Bot Garden, Guangzhou 510650, Peoples R China 4.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 6.Guangxi Normal Univ, Sate Key Lab Chem & Mol Engn Med Resources, Nanning, Peoples R China |
| Recommended Citation GB/T 7714 | Wang,Yingjie,Chen,Gang,Meng,Qingqi,et al. Potential inhibitors of microglial activation from the roots of Vernicia montana Lour[J]. PHYTOCHEMISTRY,2022,194:113019. |
| APA | Wang,Yingjie.,Chen,Gang.,Meng,Qingqi.,Yao,Xiaohu.,Li,Yang.,...&Li,Ning.(2022).Potential inhibitors of microglial activation from the roots of Vernicia montana Lour.PHYTOCHEMISTRY,194,113019. |
| MLA | Wang,Yingjie,et al."Potential inhibitors of microglial activation from the roots of Vernicia montana Lour".PHYTOCHEMISTRY 194(2022):113019. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment