Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production

doi:10.1016/j.bioorg.2021.104635

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	Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production
	Dai,Chong ; Li,Xiaoxin ; Zhang,Kailin ; Li,Xiao-Nian ; Wang,Wenjing ; Zang,Yi ; Chen,Xia ; Li,Qin ; Wei,Mengsha ; Chen,Chunmei ; Zhu,Hucheng ; Zhang,Yonghui
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	108 页码:104635
摘要	Eleven undescribed quinolone alkaloids, pesimquinolones I-S (1-4 and 6-12), as well as eleven known congeners (5 and 13-22), were isolated from the solid culture broth of the fungus Penicillium simplicissimum. Their chemical structures with absolute configurations were established by a combination of NMR spectroscopy, single-crystal X-ray crystallography, and modified Mosher's methods. Pesimquinolones I-K (1-3) represent the first examples of natural occurring quinolone alkaloids that possess a 6/6/6/6 tetracyclic ring system. The anti-inflammatory activities of selected compounds on LPS-induced nitric oxide (NO) production in adherent cells were evaluated. Compounds 1 and 2 showed suppressive effects on the production of NO, with IC50 values of 10.13 and 8.10 mu M, respectively.
关键词	Penicillium simplicissimum Quinolone alkaloids inhibitory activity on NO production
DOI	10.1016/j.bioorg.2021.104635
WOS记录号	WOS:000624557000005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73001
专题	中国科学院昆明植物研究所
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 3.Hubei Hualong Biochem Pharmaceut Ltd Co, Xiaogan 432800, Peoples R China
推荐引用方式 GB/T 7714	Dai,Chong,Li,Xiaoxin,Zhang,Kailin,et al. Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production[J]. BIOORGANIC CHEMISTRY,2021,108:104635.
APA	Dai,Chong.,Li,Xiaoxin.,Zhang,Kailin.,Li,Xiao-Nian.,Wang,Wenjing.,...&Zhang,Yonghui.(2021).Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production.BIOORGANIC CHEMISTRY,108,104635.
MLA	Dai,Chong,et al."Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production".BIOORGANIC CHEMISTRY 108(2021):104635.