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Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production
Dai,Chong; Li,Xiaoxin; Zhang,Kailin; Li,Xiao-Nian; Wang,Wenjing; Zang,Yi; Chen,Xia; Li,Qin; Wei,Mengsha; Chen,Chunmei; Zhu,Hucheng; Zhang,Yonghui
2021
Source PublicationBIOORGANIC CHEMISTRY
ISSN0045-2068
Volume108Pages:104635
AbstractEleven undescribed quinolone alkaloids, pesimquinolones I-S (1-4 and 6-12), as well as eleven known congeners (5 and 13-22), were isolated from the solid culture broth of the fungus Penicillium simplicissimum. Their chemical structures with absolute configurations were established by a combination of NMR spectroscopy, single-crystal X-ray crystallography, and modified Mosher's methods. Pesimquinolones I-K (1-3) represent the first examples of natural occurring quinolone alkaloids that possess a 6/6/6/6 tetracyclic ring system. The anti-inflammatory activities of selected compounds on LPS-induced nitric oxide (NO) production in adherent cells were evaluated. Compounds 1 and 2 showed suppressive effects on the production of NO, with IC50 values of 10.13 and 8.10 mu M, respectively.
KeywordPenicillium simplicissimum Quinolone alkaloids inhibitory activity on NO production
DOI10.1016/j.bioorg.2021.104635
WOS IDWOS:000624557000005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73001
Collection中国科学院昆明植物研究所
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
3.Hubei Hualong Biochem Pharmaceut Ltd Co, Xiaogan 432800, Peoples R China
Recommended Citation
GB/T 7714
Dai,Chong,Li,Xiaoxin,Zhang,Kailin,et al. Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production[J]. BIOORGANIC CHEMISTRY,2021,108:104635.
APA Dai,Chong.,Li,Xiaoxin.,Zhang,Kailin.,Li,Xiao-Nian.,Wang,Wenjing.,...&Zhang,Yonghui.(2021).Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production.BIOORGANIC CHEMISTRY,108,104635.
MLA Dai,Chong,et al."Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production".BIOORGANIC CHEMISTRY 108(2021):104635.
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