Indole alkaloids with self-activated sp(2) C-H bond from Alstonia scholaris
Wei, Xin2,3; Qin, Xu-Jie2; Jin, Qiong2; Yu, Hao-Fei2; Ding, Cai-Feng2; Khan, Afsar4; Liu, Ya-Ping2; Xia, Chengfeng1; Luo, Xiao-Dong1,2
Corresponding AuthorXia, Chengfeng(xiacf@ynu.edu.cn) ; Luo, Xiao-Dong(xdluo@mail.kib.ac.cn)
2020-05-21
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume61Issue:21Pages:5
AbstractAlstoniascholarines T (1) and U (2), two novel monoterpenoid indole alkaloids from Alstonia scholaris, enabled an unexpected deuteration via activation of the sp(2) C-H bond without any catalysts under room temperature. Structurally, alkaloid 1 represented the rare nor-C-17 strychnan indole, and compound 2 possessing highly modified strychnan skeleton with an additional furan ring between C-16/19. This finding presented the detailed description of natural products with sp(2) C-H self activation and deuteration, which may shed a light on the C - H functionalization blocked by the expensive metal catalysts and/or rather harsh reaction conditions. (C) 2020 Elsevier Ltd. All rights reserved.
KeywordAlstonia scholaris Indole alkaloids Nor-C-17 strychnan C-H self-activation
DOI10.1016/j.tetlet.2020.151894
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000531102800012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71817
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorXia, Chengfeng; Luo, Xiao-Dong
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Guizhou Univ Tradit Chinese Med, Guiyang 550025, Peoples R China
4.COMSATS Univ Islamabad, Dept Chem, Abbottabad Campus, Abbottabad 22060, Pakistan
Recommended Citation
GB/T 7714
Wei, Xin,Qin, Xu-Jie,Jin, Qiong,et al. Indole alkaloids with self-activated sp(2) C-H bond from Alstonia scholaris[J]. TETRAHEDRON LETTERS,2020,61(21):5.
APA Wei, Xin.,Qin, Xu-Jie.,Jin, Qiong.,Yu, Hao-Fei.,Ding, Cai-Feng.,...&Luo, Xiao-Dong.(2020).Indole alkaloids with self-activated sp(2) C-H bond from Alstonia scholaris.TETRAHEDRON LETTERS,61(21),5.
MLA Wei, Xin,et al."Indole alkaloids with self-activated sp(2) C-H bond from Alstonia scholaris".TETRAHEDRON LETTERS 61.21(2020):5.
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