Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) FH Chen That Function in Treatment of Hyperlipidemia and Obesity
Wang, Qian3,5; Mu, Rong-Fang3,5; Liu, Xing2; Zhou, Hui-Min3,5; Xu, Yu-Hui3,6; Qin, Wan-Ying3,5; Yang, Chong-Ren2,3; Wang, Li-Bin1; Li, Hai-Zhou2; Xiong, Wen-Yong1,3,4
Corresponding AuthorWang, Li-Bin(wanglibin007@126.com) ; Li, Hai-Zhou(651125836@qq.com) ; Xiong, Wen-Yong(xwy@ynu.edu.cn)
2020-04-29
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume68Issue:17Pages:4865-4875
AbstractSaponins of Panax notoginseng (Burk.) F.H. Chen have been classified as a type of composition in functional foods for numerous diseases. However, its mild effects and other characteristics limited clinical applications in diseases. Inspired by "nine steaming and nine processing" of P. notoginseng in traditional Chinese medicine, we developed a "steaming"-mimic protocol, which significantly changed the composition of saponins of P. notoginseng from the original, R1, Rg1, Re, Rb1, and Rd (raw-PNS), to the products after steaming, 20S/R-Rh1, Rk3, Rh4, 20S/R-Rg3, Rk1, and Rg5 (N-PNS). Surprisingly, N-PNS demonstrated promising activities in improving hyperlipidemia and reducing body weight and weight of white adipose tissue and the inhibition of adipogenesis in obese mice. In accordance with the results in vivo, N-PNS remarkably blunted adipogenesis at the early stage of differentiation dose-dependently in vitro. Moreover, we demonstrated that the activity may involve the adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway by promoting phosphorylation of AMPK(T172) and downregulating its downstream factors: sterol regulatory element binding protein 1c, stearoyl-CoA desaturase 1, and fatty acid synthase. Taken together, the steaming-induced eight compositions of saponins showed a very promising function in improving hyperlipidemia and obesity both in vivo and in vitro, providing fundamental evidence for future study and application in treatment of hyperlipidemia, obesity, and other lipid-related metabolic syndromes.
Keywordhyperlipidemia obesity Panax notoginseng saponins steaming AMPK
DOI10.1021/acs.jafc.0c00746
Indexed BySCI ; SCI
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000529960100013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71790
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorWang, Li-Bin; Li, Hai-Zhou; Xiong, Wen-Yong
Affiliation1.Ningxia Med Univ, Biochip Res Ctr, Gen Hosp, Yinchuan 750001, Ningxia, Peoples R China
2.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Ctr Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Yunnan Univ, Key Lab Med Chem Nat Resource, Kunming 650500, Yunnan, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Kunming Med Univ, Sch Basic Med Sci, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qian,Mu, Rong-Fang,Liu, Xing,et al. Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) FH Chen That Function in Treatment of Hyperlipidemia and Obesity[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(17):4865-4875.
APA Wang, Qian.,Mu, Rong-Fang.,Liu, Xing.,Zhou, Hui-Min.,Xu, Yu-Hui.,...&Xiong, Wen-Yong.(2020).Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) FH Chen That Function in Treatment of Hyperlipidemia and Obesity.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(17),4865-4875.
MLA Wang, Qian,et al."Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) FH Chen That Function in Treatment of Hyperlipidemia and Obesity".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.17(2020):4865-4875.
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