Triterpenoid saponins with hepatoprotective effects from the fresh leaves of Metapanax delavayi
Wei, Xin1,2; Gao, Da-Fang1; Abe, Yuko3; Tanaka, Yoshihisa3; Zhu, Hong-Tao1,4; Wang, Dong1,4; Yang, Chong-Ren1; Zhang, Ying-Jun1,4
Corresponding AuthorZhang, Ying-Jun(zhangyj@mail.kib.ac.cn)
2020-05-18
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume34Issue:10Pages:1373-1379
AbstractThe fresh leaves of Metapanax delavayi (Araliaceae) have been used as a common wild vegetable for salad and soup, and also herbal tea by the local people living in its growing areas of Yunnan province, China. Detailed chemical investigation led to the identification of a new triterpenoid saponin, 3-O-alpha-L-arabinopyranosyl-28-O-beta-D-glucopyranosyl-(1 -> 6)-O-beta-D-glucopyranosyl-3 beta-hydroxyolean-12-ene-28,29-dioic acid (1) from the fresh leaves, together with 11 known compounds, including six triterpenoid saponins (2-7), two caffeoylquinic acid derivatives (8-9), and three flavonoid glycosides (10-12). Their structures were determined on the basis of spectroscopic analysis and acidic hydrolysis. Compounds 3-5 and 8-12 were isolated from M. delavayi for the first time. Moreover, the known saponins 3-O-beta-D-xylopyranosyl-3 beta-hydroxyolean-12-ene-28,29-dioic acid (3) and yiyeliangwanoside IV (5) exhibited protective effects on HepG2 cells damaged by the alcohol intakes, at a concentration of 1.0 mu g/mL. The results indicated M. delavayi is an ideal dietary vegetable and herbal tea with potential hepatoprotective activity. [GRAPHICS] .
KeywordAraliaceae Metapanax delavayi triterpenoid saponins hepatoprotective activity
DOI10.1080/14786419.2018.1512987
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000533706100005
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71751
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhang, Ying-Jun
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Guiyang Univ Chinese Med, Guiyang, Peoples R China
3.Asahi Brewery Co Ltd, Res & Dev Ctr, Ibaraki, Japan
4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wei, Xin,Gao, Da-Fang,Abe, Yuko,et al. Triterpenoid saponins with hepatoprotective effects from the fresh leaves of Metapanax delavayi[J]. NATURAL PRODUCT RESEARCH,2020,34(10):1373-1379.
APA Wei, Xin.,Gao, Da-Fang.,Abe, Yuko.,Tanaka, Yoshihisa.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2020).Triterpenoid saponins with hepatoprotective effects from the fresh leaves of Metapanax delavayi.NATURAL PRODUCT RESEARCH,34(10),1373-1379.
MLA Wei, Xin,et al."Triterpenoid saponins with hepatoprotective effects from the fresh leaves of Metapanax delavayi".NATURAL PRODUCT RESEARCH 34.10(2020):1373-1379.
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